Introduced a few years ago as our new annual feature, here, we publish the list of the top twenty-five readers’ favorite BrainImmune stories of 2020.
Our #1 most-read story this year is Thyroid Hormone Modulation of Immune Responses in Physiologic And Stressful Conditions. This review is authored by Graciela Cremaschi and Ana Maria Genaro from the National Scientific and Technical Research Council, Buenos Aires, Argentina. As discussed by these authors: “interactions between thyroid hormones and the immune system are important to elicit appropriate immune responses, especially when the immune system is challenged as in stressful conditions”.
Walter Bradford Cannon, one of America’s leading physiologists, and former Chairman of the Department of Physiology at Harvard Medical School (1906-1942), invented the terms and developed the concepts of ‘homeostasis’ (stability of the inner world); the ‘Fight or Flight Response’, and The ‘Sympathoadrenal System’. In 1932, Cannon published The Wisdom of the Body, where he popularized the new term of the dynamic equilibrium/steady state of the internal milieu or homeostasis.
Major depression is a common but serious mood disorder, where both neuroendocrineand immunedysfunctions play major roles. It is also known that major depression contributes to serious health hazards such as the development of cardiovascular diseases. Thus, social media overuse may in fact be linked to health risks and a neuroendocrine-immune dysfunction.
Interestingly, the short blog-style post Chronic Urticaria Linked to a Th2/Th17 Shift in Skin Lesions (#5) was an unexpected article to appear on the most-read list. This may simply indicate a relatively high readership interest about new evolving immune or neuroendocrine-immune mechanisms contributing to urticaria such as T helper (Th)2 and/or Th17 shift. Or, another explanation may be the mechanisms involving the association between psychological stress and urticaria. This may also indicate a similar mechanism in Graves’ disease as outlined in another BrainImmune article mentioned above: ‘Stress-Induced Th2 Shift & Thyroid Autoimmunity: Unifying Hypothesis’.
are really unique in that the Hans Selye stress concept, and the discovery of interferon, are written by Profs. Istvan Berczi and Derek Burke, two investigators who had the chance to work along Hans Selye and Alick Isaacs, respectively.