Hans Selye and the Birth of the Stress Concept

In 1936 a half page report appeared in Nature magazine under the title “A syndrome produced by diverse nocuous agents,” which was authored by Hans Selye of McGill University, Montreal, Canada [1]. The essence of this report was that rats exposed to a variety of nocuous or toxic agents (e.g. cold, surgery, forced exercise, adrenaline, atropine, morphine, formaldehyde, etc.) responded to these diverse stimuli with pathophysiological changes that had some common features. The enlargement of the adrenals, the profound shrinkage … Continue reading Hans Selye and the Birth of the Stress Concept