Evidence for Small Fiber Neuropathy in the Cornea of Fibromyalgia Patients

Small Fiber Neuropathy in the Cornea of Fibromyalgia Patients

A new study published in Seminars in Arthritis & Rheumatism indicates that in patients with fibromyalgia the density of small nerve fibers in the cornea is reduced, supporting an evolving concept that fibromyalgia is a small fiber neuropathy.

Fibromyalgia is also considered a stress-related syndrome that affects predominantly women. Recent research suggests that fibromyalgia is a neuropathic syndrome affecting small sensory and sympathetic nerve fibers resulting in pain, paresthesias and autonomic dysfunction.

Thus, skin biopsies of fibromyalgia patients show a reduction in intra epidermal innervation and regeneration sparing myelinated nerve fibres (N Üçeyler et al., 2013).

The cornea receives an extremely dense small fiber innervation, and the corneal confocal bio-microscopy is a new non-invasive method that can assess nerve fiber morphology and pathology.

In the Seminars in Arthritis & Rheumatism study Manuel Ramírez and colleagues, from the National Institute of Cardiology, Mexico City, Mexico, studied the cornea’s small fiber innervation in 17 female patients diagnosed with fibromyalgia. The authors demonstrate that fibromyalgia patients have thinner/smoother corneal stromal nerves and decreased corneal sub-basal nerve plexus density when compared to healthy controls.

These results indicate that, in fibromyalgia, the small fiber neuropathy is not limited to the skin, but also present in the cornea. The authors suggest that fibromyalgia pain is sympathetically-driven and closely associated with an autonomic/sympathetic nervous system dysfunction.

According to them, in the future, a more refined and comprehensive corneal bio-microscopy may become a non-invasive diagnostic tool for small fiber neuropathy such as fibromyalgia.

Source: Seminars in Arthritis & Rheumatism. 2013. Accepted Manuscript. DOI: 10.1016/j.semarthrit.2015.03.003

Read more: Seminars in Arthritis & Rheumatism

Cover Image: Confocal images of corneal subbasal nerves obtained from 2 types of confocal microscope: (A) Laser scanning confocal microscope (LSCM) and (B) Slit-scanning confocal microscope (SSCM). From: Characteristics of Corneal Subbasal Nerves in Different Age Groups: An in vivo Confocal Microscopic Analysis. By Chirapapaisan C , Thongsuwan S, Chirapapaisan N, Chonpimai P, Veeraburinon, DovePress. 24 August 2021 Volume 2021:15 Pages 3563—3572. Public domain. https://www.dovepress.com/characteristics-of-corneal-subbasal-nerves-in-different-age-groups-an–peer-reviewed-fulltext-article-OPTH

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