An Association between Widespread Pain and Serum IL-8 Levels in Fibromyalgia Patients


Ozdolap S, et al. recently reported, at the European League against Rheumatism Annual European Congress of Rheumatology, June 10-13, 2015, a positive correlation between widespread pain and serum IL-8 in patients with fibromyalgia (FM).

Fibromyalgia is characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues, and women are more likely to develop fibromyalgia than are men. Recent evidence indicates that cytokines and especially chemokines contribute to the pathogenesis of FM.

The work of Ozdolap S, et al. substantiates previous work indicating that the pro-inflammatory chemokine IL-8 may contribute to the pathogenesis of fibromyalgia (Wang H. et al., 2009).

Of note, higher cerebrospinal fluid (CSF) levels of IL-8 in FM patients were also recently reported (Kadetoff D. et al., 2012; Kosek E. et al., 2015). Interestingly, exercise interventions might exert an anti-inflammatory effect, as exercise appear to reduce serum IL-8 and IL-6 levels.

IL-8, also known as neutrophil chemotactic factor is a chemokine known to activate neutrophils and is an important factor for the migration and infiltration of neutrophils at inflammation sites.

Other pro-inflammatory cytokines, such as interleukin (IL)-17A might also be involved in the development of FM.

The role of IL-8, in general, as a mediator of pain was first suggested by F.Q. Cunha et al. back in 1991.

Read More:

Related stories you may like:
Sympathetic Dysautonomia in Fibromyalgia
CX3CL1 and IL-8 Implicated in the Pathogenesis of Fibromyalgia
Small Fiber Neuropathy in the Cornea of Fibromyalgia Patients
Evidence Linking IL-17 to Neuropathic Pain