BrainImmune - Trends In Neuroendocrine Immunology

Host Viral Resistance IFN Liver NK Cells

Beta-adrenoceptor Activation Reduces Host Viral Resistance by Preventing IFN-γ Production in Liver NK Cells

The Brain Glymphatic System: From a Good Night’s Sleep to the Onset of Dementia

Stress, Dyshomeostasis and COVID-19 Mortality: A Big Picture View

β2-Adrenergic Agonists for Parkinson’s Disease: Repurposing Drugs at the Crossroad of the Brain and the Immune System

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Brainimmune is Looking for a Strategic Partner to Advance the Neuroendocrine Immunology and Stress-Immunity Research Field

Role of Peripheral Immunity in Cognitive Decline During Parkinson’s Disease

Experimental Study Shows that Learned Immunosuppressive Placebo Responses Attenuate Disease Progression in a Rat Model of Arthritis

Neural Suppression Neutralizes Flesh-Eating Streptococcal Bacterial Infection

FEATURED

Neuroendocrine Phenotypes Immune Responses Avian Species

Neuroendocrine Phenotypes that Affect Immune Responses in Mammals Found in Avian Species

A cooperative study by Argentinian and UK research teams published in the PLOS ONE journal showed that the individual’s neuroendocrine phenotypes found in mammals, such as rodents and humans, that influence the host’s immune responses, is an evolutive trait traced back to birds such as quails. Numerous previous studies indicate...

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BrainImmune’s Most-Read Stories of 2021

Encouraging Results Oral Antiviral Molnupiravir

Encouraging Results from Phase 2a COVID-19 Clinical Trial with the Oral Direct-Acting Antiviral Molnupiravir

The New US Antiviral Program for Pandemics

platelet-activating anti-PF4 antibodies vaccine-induced immune thrombotic thrombocytopeniat

New evidence linking platelet-activating anti-PF4 antibodies to the vaccine-induced immune thrombotic thrombocytopenia

Identification of GM-SCF as possible distinctive blood marker predicting severe COVID-19

COVID-19 and Cardiovascular Diseases Surge

Monogenic immune defects in type I interferon pathways as a risk factor for severe COVID-19 pneumonia

EDITORIALS & OPINION | COMMENTARIES

The IL-6 Inhibitors Tocilizumab and Sarilumab and COVID-19 Treatment: Controversies but Potential Efficacy in Severe Cases

New Evidence for Key Factors that Drive COVID-19 Severity

new Adrenoceptor Upregulation IL-17 COVID-19

β2-Adrenoceptor-Mediated Upregulation of IL-17 May Contribute to Pulmonary Immunopathology in COVID-19: Does Blockade of IL-17 and β-Adrenergic Effects Hold a Therapeutic Potential?

Parkinson’s Disease: Peripheral Immunity Links Neurodegeneration and the Intestinal Microbiota

Neuroendocrine Immune Implications in Rheumatoid Arthritis and Polymyalgia Rheumatica: Past and Present Unresolved Issues and Optimising Glucocorticoid Treatment

EVOLVING CONCEPTS

The Emerging Role of Neuro-Immune Synapses and the Immunological Homunculus in the Context of the Systematic Lymphoid Organs Innervation

Microglia: gatekeepers for neuropathic pain

The Cross-talk between the Dopaminergic System and Innate Immunity: An Evolving Concept

An Evolving Concept: The Pathologic Level of Brain TNF is a Therapeutic Target for Chronic Pain Treatment

Understanding the Role of Inflammation in Fatigue Requires Multidimensional Assessments

STRESS & IMMUNITY

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

Psychosocial Stress and Chronic Viral Hepatitis

Stress and Cancer: A Link Through the Chinese Cultural Revolution

The Link Between Stress, Emotions and Cytokine-Related Diseases

Pro- and Anti-Inflammatory Effects of Stress in the Brain: Mechanisms and Implications

FUNDAMENTALS

Disruption of Brain TNF Homeostasis Elicits Maladaptive Alterations Producing Chronic Pain

Acid Sensing By Sensory Neurons in Inflammation

Chronic inflammatory conditions, such as rheumatoid arthritis (RA), are characterized by continuous pain and RA is the most frequent form of inflammatory joint disease in the United Kingdom [1] with an estimated economic cost of...

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

The catecholamines dopamine, noradrenaline and adrenaline are well established neurotransmitters and neurohormones. Sympathoadrenergic pathways are pivotal to the communication between the nervous system and the immune system, and the role of dopaminergic pathways in the...

CLINICAL OVERVIEWS

Sex Steroids Hormones and Autoimmune Disease Activity

Edith Piaf, the famed French singer also had severe rheumatoid arthritis (see more, Cover Image below). Females display an increased incidence of autoimmune diseases, with a sexual dimorphism in the...

Neuroendocrine-Immune Interactions in Lung Inflammatory Diseases

Inflammation is the body’s response to insults. During inflammation, various inflammatory cells are activated to release cytokines and mediators and orchestrate progressing inflammation. Clinically, pneumonia and acute respiratory distress syndrome...

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