The Wiley-Blackwell Handbook of Psychoneuroimmunology

Wiley-Blackwell Handbook PsychoneuroimmunologyThe Wiley-Blackwell Handbook of Psychoneuroimmunology is edited by Alexander W. Kusnecov, an associate professor of psychology at Rutgers University, USA and Hymie Anisman, Professor in the department of Neuroscience, Carleton University, Canada, and a distinguished Canada Research Chair in Neuroscience. The book delivers the history, methodology and development of research into psychoneuroimmunology, balancing it with meticulous coverage of both the clinical aspects and practical applications of the subject.

The background material in the Handbook of Psychoneuroimmunology is balanced by a detailed assessment of emerging topics in psychoneuroimmunology research that focuses on the clinical and practical implications of findings from empirical studies on both humans and animals. While specialist readers will appreciate the coverage of progress made in psychoneuroimmunology, newcomers will gain much from its informed and accessible introduction to the field, as well as its exploration of a variety of methodological approaches.

Specific issues and topics discussed in this book include: Basic principles in immunology; the innervation of the immune system and neural functions of hematopoietic‐derived cells; the immune–neuroendocrine network in health and immunoregulatory neuropeptides; the regulation of immune cell activity by norepinephrine and the β2‐adrenergic receptor involvement; the immune‐to‐brain communication in pain; stress and immunity, and aging and the immune system.

Also, the inflammatory roads to neurodegeneration: a focus on Parkinson’s and Alzheimer’s disease; the interaction between immune and energy‐balance signals in the regulation of feeding and metabolism.

A special chapter is dedicated the neuroimmune mechanisms associated with autism. This section discusses the evidence that abnormal maternal immune responses during pregnancy contribute to the etiology of autism. It also discusses how an array of insults to the immune system may give rise to the spectrum of symptoms in autism. It introduces the key cellular components which mediate immune responses in the central and peripheral nervous system, and how they are altered in autism.

Hardcover: 552 pages; Publisher: Wiley-Blackwell; 1 edition (December 31, 2013)

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