Tumor Necrosis Factor Modulates Bitter Taste Responses

Tumor Necrosis Factor Modulates Bitter Taste Responses

A new study by Pu Feng and colleagues from the Monell Chemical Senses Center, Philadelphia, USA, published in Brain, Behavior, and Immunity indicates that tumor necrosis factor (TNF)-α, a major pro-inflammatory cytokine is involved in the regulation of bitter taste reception.

Whether inflammatory cytokines contribute to taste reception or regulation is poorly understood.

TNF is known to be part of the cause of ‘sickness behavior’ including fatigue, malaise, depression, and anorexia and to induce significant reduction in food intake both in rodents and in humans. Previous research also indicates that some pro-inflammatory cytokines are expressed in taste bud cells but not in nontaste lingual epithelial cells.

The Brain, Behavior, and Immunity study reports that TNF-deficient mice are less responsive to bitter compounds than control mice. The authors of this study suggested that during physiological conditions, TNF preferentially sensitizes bitter taste responses. However, under inflammatory conditions, when the TNF production is enhanced in taste buds, TNF may affect other types of taste cells in addition to its effect on bitter cells.

According to the authors these phenomena and mechanisms may contribute to taste dysfunction associated with some infections or inflammatory conditions.

Source: Brain Behav Immun. 2015 Apr 21. pii: S0889-1591(15)00086-0. doi: 10.1016/j.bbi.2015.04.001. [Epub ahead of print]

Read more: sciencedirect.com
monell.org/news

 

Source: Cover Image: Taste buds. Approximately ten thousand taste buds located on the surface of the tongue detect the five basic tastes: sweet, sour, salty, bitter, and umami. Each taste bud contains three different types of elongated taste cells (Type I, Type II, and Type III). Each of these sensory neurons has a different mechanism for transducing a specific taste signal to the brain. Type I glial-like cells detect the salty taste, while Type III presynaptic cells sense the sour taste. Type II receptor cells recognize sweet, bitter, and umami tastes by expressing different types of G protein-coupled receptors (GPCRs). Credit: knowingneurons.com http://knowingneurons.com/2013/04/01/new-ion-channel-identified-for-the-neurotransmission-of-sweet-bitter-and-umami-tastes/

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