Takotsubo (Stress) Cardiomyopathy, an Issue of Heart Failure Clinics

Takotsubo (Stress) CardiomyopathyTakotsubo (Stress) Cardiomyopathy, an Issue of Heart Failure Clinics is authored by Eduardo Bossone and Raimund Erbel, and published by Elsevier.

Stress-induced cardiomyopathy, also known as “Takotsubo” cardiomyopathy, broken heart syndrome and apical ballooning syndrome, was first described in Japan, in 1990, by Sato et al.

Stress-induced cardiomyopathy represents a transient left ventricle systolic dysfunction with electrocardiographic changes that can mimic acute myocardial infarction and minimal release of myocardial enzymes in the absence of obstructive coronary artery disease.

Recent research indicates that myocardial inflammation is an important component of the pathophysiology behind stress-induced cardiomyopathy. Specifically, the stress-induced inflammation, and mostly catecholamine-induced inflammation, might represent the driving force leading to the development of acute symptoms and transiently altered ventricular contractility.

Moreover, a recent PNAS study found that the acute heart injury induced by an experimental PTSD stress model is associated with underlying biological injury processes and alterations of key molecular processes, including an inflammatory response. According to the authors of this study, the finding of acute heart injury in this PTSD animal model suggests common stress-induced heart impairment.

The Takotsubo (Stress) Cardiomyopathy book, in this issue of Heart Failure Clinics, covers stress (takotsubo) cardiomyopathy. Expert authors review the most current information available about imaging modalities, clinical profile, natural history, management, and different types of stress cardiomyopathy. Keep up-to-the-minute with the latest developments in diagnosing and managing this condition.

Series: The Clinics: Internal Medicine (Book 9); Hardcover: 269 pages; Publisher: Elsevier; 1 edition (April 26, 2013).

About the Authors: Eduardo Bossone, Affiliations and Expertise, University of Salerno, Italy; Raimund Erbel, Affiliations and Expertise, University Duisburg-Essen, Essen, Germany.

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