vitamin D and autoimmunity

1,25-Dihydroxyvitamin D3 Transcriptional Repression of Interleukin-17A Expression and Th17-Related Autoimmunity

1,25-Dihydroxyvitamin D3 Transcriptional Repression of Interleukin-17A Expression and Th17-Related Autoimmunity

In a new Molecular and Cellular Biology study, Sneha Joshi and colleagues from the University of Medicine and Dentistry of New Jersey, Newark demonstrate that the reversal of paralysis in EAE mice by 1,25-Dihydroxyvitamin D3 correlates with reduced IL-17A-secreting CD4+ T cells, and that the mechanism involved in 1,25-Dihydroxyvitamin D3-mediated suppression of IL-17A induction involves […]