TRPV1 pain receptor

Neural Suppression Neutralizes Flesh-Eating Streptococcal Bacterial Infection

Neural Suppression Neutralizes Flesh-Eating Streptococcal Bacterial Infection

In a recent study published in the journal Cell, Pinho-Ribeiro et al. report that a specific type of bacteria (S. pyogenes), involved in necrotizing fasciitis, increases its infectivity and inhibits tissue immune responses by stimulating local pain neurons. This mechanism suggests that local block of neural activity can be used to increase bacteria clearance and […]

The TRPV1 Pain Receptor is Expressed and Functionally Active in Human T Lymphocytes

The TRPV1 Pain Receptor is Expressed and Functionally Active in Human T Lymphocytes

A study published in Nature Immunology reveals a previously unrecognized, ‘non-canonical’ role of the pain TRPV1 receptor – namely, its functional expression, and involvement in TCR signaling and pro-inflammatory activities of T cells. Transient receptor potential vanilloid type 1 ion channel (TRPV1), initially identified as the receptor for capsaicin (the hot ingredient of chilli peppers) […]