Treg cells

Interleukin-35 Restrains Lymphocytic Infiltration and T Cell-Dependent Anti-Tumor Immunity

Interleukin-35 Restrains Lymphocytic Infiltration and T Cell-Dependent Anti-Tumor Immunity

A new study published in the journal Immunity indicates that interleukin (IL)-35 inhibits the recruitment of effector anti-tumor T cells and suppresses their function in the tumor microenvironment. IL-35 belongs to the IL-12 family of cytokines. It is a dimeric protein composed of two subunits – p35 and EBI3, which are shared with other IL-12 […]