Th17 and hormone

Melatonin May Control the Balance between Pathogenic Th17 and Regulatory T Cells

Melatonin May Control the Balance between Pathogenic Th17 and Regulatory T Cells

Commentary on the study by Mauricio Farez et al., 2015, Cell, 162, 1338–1352 Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses‘ The central master circadian clock is located in the suprachiasmatic nucleus (SCN). The output of this system is synchronized to 24 hours by the light-dark cycle. The SCN regulates rhythms in peripheral cells via […]

Vasoactive Intestinal Peptide Inhibits Pathogenic Th17 Cells from Rheumatoid Arthritis Patients

Vasoactive Intestinal Peptide Inhibits Pathogenic Th17 Cells from Rheumatoid Arthritis Patients

A study published in the Journal of Leukocyte Biology indicates that in blood from rheumatoid arthritis (RA) patients, vasoactive intestinal peptide (VIP) shifts the activity of T cells towards a more T regulatory cell phenotype, and reduces the pathogenic profile of T helper (Th)17 cells. The vasoactive intestinal peptide (VIP) is well-known for its immunoregulatory […]

Glucocorticoid Resistance of Th17 Cells in Takayasu Arteritis

Glucocorticoid Resistance of Th17 Cells in Takayasu Arteritis

A study published in the Arthritis & Rheumatology journal is perhaps the first to demonstrate that T helper (Th)1 and Th17 cells and cytokine pathways may play central role in driving systemic inflammation in Takayasu arteritis. Takayasu arteritis (TA) is a rare type of vasculitis that affects mostly middle-aged women, with greater frequency in Asia, […]

Sperm-Induced Th17 Immune Responses and Their Control by Sex Hormones: Implications for Fertility

Sperm-Induced Th17 Immune Responses and Their Control by Sex Hormones: Implications for Fertility

A new study by Miguel Relloso and colleagues from the Hospital General Universitario Gregorio Marañón in Madrid, Spain, identifies the female sex hormones as important regulators of the T helper (Th)17 response induced by sperm, and related to dendritic cells (DCs), the key professional antigen-presenting cells. Sperm is a foreign antigen (material) and its contact […]

Adiponectin potentiates Th1 and Th17 immune responses

Adiponectin potentiates Th1 and Th17 immune responses

A new study published in March 2013 issue of the Journal of Immunology identifies a new immunomodulatory effect of adiponectin (APN) – its ability to activate DCs through PLCγ/JNK/NF-κB-signaling pathways and release of proinflammatory cytokines, and to potentiate Th1 and Th17 immune responses. Adiponectin, the most abundant adipokine, is known for its insulin-sensitizing effects, is […]

Activation of Beta2-Adrenoreceptors Drives T Helper Cell Priming In Favor of IL-17 Responses

Activation of Beta2-Adrenoreceptors Drives T Helper Cell Priming In Favor of IL-17 Responses

In a recent study published in the journal Cytokine, Michela Manni, Richard Granstein and Georges Maestroni, from the Center for Experimental Pathology, Locarno, Switzerland, provide new evidence suggesting that catecholamines, through activation of beta2-adrenoreceptors (ARs) on immune cells, may drive, in certain conditions, Th17 immune responses. The authors report that the beta2-AR agonist salbutamol is […]

1,25-Dihydroxyvitamin D3 Transcriptional Repression of Interleukin-17A Expression and Th17-Related Autoimmunity

1,25-Dihydroxyvitamin D3 Transcriptional Repression of Interleukin-17A Expression and Th17-Related Autoimmunity

In a new Molecular and Cellular Biology study, Sneha Joshi and colleagues from the University of Medicine and Dentistry of New Jersey, Newark demonstrate that the reversal of paralysis in EAE mice by 1,25-Dihydroxyvitamin D3 correlates with reduced IL-17A-secreting CD4+ T cells, and that the mechanism involved in 1,25-Dihydroxyvitamin D3-mediated suppression of IL-17A induction involves […]