tertiary lymphoid organs

Th17 Cells and Lymphotoxin: Conductors for the Tertiary Lymphoid Tissues and Inflammation Orchestra

Th17 Cells and Lymphotoxin: Conductors for the Tertiary Lymphoid Tissues and Inflammation Orchestra

Commentary on the study by Natalia Pikor et al., Immunity, 2015, 43:1160-73. doi: 10.1016/j.immuni.2015.11.010 Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation Tertiary lymphoid organs, or more properly, tertiary lymphoid tissues (TLTs), are accumulations of lymphoid tissues that arise in situations of chronic inflammation. TLTs have been shown to […]

Th17 Cells and Lymphotoxin Promote Tertiary Lymphoid Tissues Formation and Neuroinflammation

Th17 Cells and Lymphotoxin Promote Tertiary Lymphoid Tissues Formation and Neuroinflammation

According to a recent study published in Immunity, T helper (Th)17 cells initiate tertiary lymphoid tissues (TLTs) development in the meninges and propagate brain neuroinflammation. Tertiary lymphoid tissues or tertiary lymphoid organs (TLOs) represent accumulations of lymphoid cells at ectopic sites (in contrast to most lymphoid tissues developing before birth) usually triggered by chronic inflammation. […]