Role of Peripheral Immunity in Cognitive Decline During Parkinson’s Disease
A recent study by Luca Magistrelli et al., published in the journal Brain Behavior and Immunity shows that patients with Parkinson’s disease (PD) and cognitive decline exhibit a preferential pro-inflammatory immune phenotype and a dysregulation in the CD4+ T regulatory compartment. Parkinson’s disease represents the second most common chronic neurodegenerative disease, and it is caused […]
Influence of the Sympathetic Nervous System on Regulatory T cells: Another Link in Neuro-Immune Interactions
Overview article Homeostatic control of the immune system is dependent on CD4, FoxP3+, NKT or antigen-specific CD4+ or CD8+ regulatory T cells. These regulatory T cells are essential to prevent or mitigate autoimmunity and the immune response to non-self antigens. Herein is an overview of our observations on the inhibition of the induction of splenic […]
Melatonin May Control the Balance between Pathogenic Th17 and Regulatory T Cells
Posted on February 26, 2016 By Georges Maestroni Commentaries
Commentary on the study by Mauricio Farez et al., 2015, Cell, 162, 1338–1352 Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses‘ The central master circadian clock is located in the suprachiasmatic nucleus (SCN). The output of this system is synchronized to 24 hours by the light-dark cycle. The SCN regulates rhythms in peripheral cells via […]