stroke

Australian Government Advances Stroke Research Targeting Neuroinflammation

Australian Government Advances Stroke Research Targeting Neuroinflammation

On 6 October 2018, the Hon Greg Hunt MP, Minister for Health, Australia, announced that the Australian Government will invest $1 million to improve recovery and rehabilitation and help stroke survivors back to work [1]. This funding includes $750,000 specifically designated for funding a clinical trial of the emerging, innovative perispinal etanercept (“PSE”) treatment for […]

TLRs-Activated Microglia Polarizes γδ T Cells towards a Neurotoxic IL-17+ γδ T Cell Phenotype: Implications for Multiple Sclerosis, Stroke and Alzheimer´s Disease

TLRs-Activated Microglia Polarizes γδ T Cells towards a Neurotoxic IL-17+ γδ T Cell Phenotype: Implications for Multiple Sclerosis, Stroke and Alzheimer´s Disease

A recent PLoS One study indicates that the cross-talk between the brain microglia and T cells that follows a microglia’s activation via Toll-like receptors (TLRs) stimulation, results in a shift of the T cells’ profile towards a neurotoxic IL-17+ γδ T cells phenotype. After the discovery of T helper (Th)17 cells in 2005, their main […]

Autonomic Nervous System Shift Linked to Infections following Acute Intracerebral Hemorrhage

Autonomic Nervous System Shift Linked to Infections following Acute Intracerebral Hemorrhage

A report in the journal Stroke indicates that a sympathetic nervous system over-activity and predominance is associated with higher rate of infection following acute intracerebral hemorrhage (ICH). Stroke is a major cause of morbidity and the third leading cause of death in the Western world. Infections occur commonly following stroke and adversely influence outcome. Pulmonary […]

Regulatory T Cells are Cerebroprotective in Acute Experimental Stroke

Regulatory T Cells are Cerebroprotective in Acute Experimental Stroke

A recent Nature Medicine study by Arthur Liesz et al. indicates that regulatory T cells (Treg) are cerebroprotective after experimental brain ischemia or stroke, and that interleukin (IL)-10 appears to be the major mediator of the cerebroprotective effects. Recent evidence indicates that inflammatory mechanisms such as up-regulation of pro-inflammatory cytokines and leukocytes’ invasion in the […]