stress-induced Th2 shift

New Evidence That Stress In Pregnancy Increases Susceptibility to Asthma In Offspring

New Evidence That Stress In Pregnancy Increases Susceptibility to Asthma In Offspring

A recent study published in the American Journal of Physiology – Lung Cellular and Molecular Physiology indicates that release of glucocorticoids (GCs) as the result of stress during pregnancy can induce asthma susceptibility in offspring. It is known that psychological stress contributes to the pathogenesis and exacerbations of asthma. One mechanism may be the capacity […]

New Animal Stress Model Links the Stress-Induced T-helper 2 Shift to Colon Cancer Growth

New Animal Stress Model Links the Stress-Induced T-helper 2 Shift to Colon Cancer Growth

In the October 2013 issue of Biochemical and Biophysical Research Communications, Ni Hou and colleagues from the Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi, China, demonstrated that a novel form of sound stress induced a T helper (Th)2 shift and that this is related to colon cancer progression in mice. Numerous epidemiological reports indicate […]

Pro- and Anti-Inflammatory Effects of Neuropeptide Y: Induction of Dendritic Cells Migration and Th2 Polarization

Pro- and Anti-Inflammatory Effects of Neuropeptide Y: Induction of Dendritic Cells Migration and Th2 Polarization

A new study in The FASEB Journal indicates that Neuropeptide Y (NPY) is able to promote migration of human monocyte-derived immature dendritic cells (DCs), and a T helper (Th)2 polarization. NPY is a neurotransmitter released by the sympathetic nervous system along with norepinephrine (noradrenaline), and elevated NPY levels are detected in conditions of acute or […]

Stress-Induced Th2 Shift & Thyroid Autoimmunity: Unifying Hypothesis

Stress-Induced Th2 Shift & Thyroid Autoimmunity: Unifying Hypothesis

Evolving Concepts Thyroid autoimmunity may manifest clinically as chronic autoimmune or Hashimoto’s thyroiditis (HT) and its variants (postpartum/sporadic thyroiditis) or as Graves’ disease (GD) and atrophic thyroiditis. These autoimmune thyroid diseases (AITD) occur as a result of aberrant immune response against thyroid antigens due to breakdown of self-tolerance [1]. Although HT and GD share a […]

Beta Blockers Hold Substantial Potential for Therapeutical Interventions in Cancer

Beta Blockers Hold Substantial Potential for Therapeutical Interventions in Cancer

Evolving Concepts Recently, more than 10 studies [see References 1-11], published in the last 3-4 years indicate the presence of high intratumoral concentrations of catecholamines and that these neurohormonal mediators affect key components of tumor biology such as tumor growth, angiogenesis, and migration or invasion [for details see References 12-13]. These studies suggest that blocking […]

Priming of Murine Bone Marrow-Derived Dendritic Cells with Epinephrine Favors the Induction of a Dominant Th2/Th17 Phenotype

Priming of Murine Bone Marrow-Derived Dendritic Cells with Epinephrine Favors the Induction of a Dominant Th2/Th17 Phenotype

A new study published in the journal Brain, Behavior, and Immunity indicates that the stress hormone epinephrine (also known as adrenaline) is able to drive a Th2/Th17-shift in dendritic cells (DCs) in the presence of a pathogenic stimulus. Dendritic cells cytokine and chemokine profiles are able to shape CD4+ T cell pathways and phenotypes and […]