stress and immune system

Childhood Adversities and the Development of Asthma in Adulthood

Childhood Adversities and the Development of Asthma in Adulthood

Recently the BMJ Open online journal published the first large-scale prospective, population-based study, involving 24 057 participants, followed for a 7-year period, documenting an association between childhood adversities and register-verified asthma diagnosis in adulthood. Previous research has shown that anxiety disorders and major depression are linked to asthma development, and two previous longitudinal studies reported […]

Accumulation of Myeloid-Derived Suppressor Cells: A New Mechanism in Favor of Stress-Induced Immunosuppression?

Accumulation of Myeloid-Derived Suppressor Cells: A New Mechanism in Favor of Stress-Induced Immunosuppression?

Jianfeng Jin et al. present a mechanism for the immunosuppressive potential of chronic stress in the September 2013 issue of PLoS One. The authors focus on myeloid-derived suppressor cells (MDSCs), which have been implicated in regulation of the innate and adaptive immune responses. In tumor microenvironments, MDSC expansion is stimulated by prostaglandin E2 (PGE2) and […]

Psychological Stress May Promote Inflammation through Expansion of Immature Proinflammatory Monocytes

Psychological Stress May Promote Inflammation through Expansion of Immature Proinflammatory Monocytes

A recent study by Nicole Powell et al. published in the October 8, 2013 issue of PNAS, suggests that stress hormones may contribute to pro-inflammation through selective expansion and/or recruitment of a specific subpopulation of immature, proinflammatory monocytes. In the 1970s and 1980s stress was often considered immunosuppressive. Recent evidence, however, indicates that psychological stress […]

Prenatal Immune Challenge – ‘Disease Primer’ Increasing the Offspring’s Vulnerability to Stress

Prenatal Immune Challenge – ‘Disease Primer’ Increasing the Offspring’s Vulnerability to Stress

A recent study published in Science is probably the first to provide evidence suggesting that prenatal immune challenge can function as a “disease primer” that amplifies the offspring’s susceptibility to stress and its detrimental neuro-pathological effects in peri-pubertal life. Epidemiologic studies indicate that prenatal infection may play an important role in the etiopathogenesis of schizophrenia, […]

Neurotensin, CRH and Mast Cell Activation: Implications for Stress-Induced Exacerbations of Allergic Diseases

Neurotensin, CRH and Mast Cell Activation: Implications for Stress-Induced Exacerbations of Allergic Diseases

A study published in PLoS One indicates the presence of distinctive interactions between neurotensin (NT), corticotropin-releasing hormone (CRH) and mast cells that may be involved in inflammatory- and/or stress-related diseases. Psychological stress is known to aggravate asthma, migraines and certain autoimmune/inflammatory diseases. Although the mechanisms of stress-induced exacerbations of these conditions are not fully understood, […]

First Evidence That Psychological Stress Alters Levels Of Suppressor Cells in Breast Cancer

First Evidence That Psychological Stress Alters Levels Of Suppressor Cells in Breast Cancer

A new study in Cellular Immunology is perhaps the first to specifically measure levels of myeloid-derived suppressor cells (MDSC) in post operative breast cancer patients who were considered to be macroscopically disease-free. In this study, Bethany Mundy-Bosse and colleagues from the Department of Integrated Biomedical Sciences, the Ohio State University, Columbus OH investigated the association […]

Effect of Catecholamines on Bacterial Growth: New Mechanism of Stress Influencing Digestive Health and Disease

Effect of Catecholamines on Bacterial Growth: New Mechanism of Stress Influencing Digestive Health and Disease

In a contemporary review, published in Cell and Tissue Research, Mark Lyte, Lucy Vulchanova and David Brown provide a brief but comprehensive overview of the actions of stress mediators, especially CAs, on enteric luminal bacteria, on gut mucosal interactions with bacteria, and on brain–gut interactions initiated by or influencing enteric bacteria. The autonomic nervous system […]

Stress May Restrain the Immunostimulatory Effects of Interleukin-12

Stress May Restrain the Immunostimulatory Effects of Interleukin-12

A new study published in the journal Brain, Behavior, and Immunity suggests that chronic stress exposure can abolish the effects of immunostimulatory treatments such as the administration of interleukin (IL)-12, which is independent from the stress effects on baseline immune measures. Type 1 T-helper (Th)1 and proinflammatory cytokines are major activators of Th1-dependent cellular immunity, […]

Psychological Stress, Immunoregulatory Balance and Human Inflammatory Diseases

Psychological Stress, Immunoregulatory Balance and Human Inflammatory Diseases

A recent review published in the journal Immunology and Allergy Clinics of North America provides a brief but comprehensive overview of the major immune mechanisms affected by stress, and the relationships linking stress with various inflammatory diseases. In this review, Gailen Marshall from the University of Mississippi Medical Center outlines recent data indicating that immunoregulatory […]

Bungee Jumping Related Stress Response May Suppress Innate Immunity Through the Activation of a Noncanonical Glucocorticoid Signaling Pathway

Bungee Jumping Related Stress Response May Suppress Innate Immunity Through the Activation of a Noncanonical Glucocorticoid Signaling Pathway

In this study, David van Westerloo and colleagues from the University of Amsterdam report that bungee jumping resulted in a time-dependent increase in the plasma concentrations of epinephrine, norepinephrine and cortisol; decreased whole blood production of TNF-alpha and IL-8, and a substantial reduction of bacterial phagocytosis by granulocytes and monocytes. Bungee jumping may represent an […]

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