stress and disease

Stress and Rheumatic Diseases

Stress and Rheumatic Diseases

SHORT FEATURES and FACES ARTICLE In an editorial published in Arthritis Research & Therapy, Afton Hassett and Daniel Clauw, of University of Michigan Medical School, discuss some aspects of the complex interactions between psychological stress and the onset, expression and progression of rheumatic diseases. The authors mention that some studies in this research area are […]

Stress: From Hans Selye to Paris Hilton

Stress: From Hans Selye to Paris Hilton

SHORT FEATURES and FACES ARTICLE In a recent FASEB editorial, Gerald Weissmann comments on the modern use of the word ‘stress’ and its evolution from Hans Selye’s original definition. According to Weissmann, the Editor-in-Chief of the FASEB journal, Selye first advanced the notion of stress as a generalized response to any insult in 1936, which […]

A Combination of Beta-Adrenergic Antagonist and Cyclooxygenase-2 Inhibitor Improves Survival Rates in Murine Models of Postoperative Metastasis

A Combination of Beta-Adrenergic Antagonist and Cyclooxygenase-2 Inhibitor Improves Survival Rates in Murine Models of Postoperative Metastasis

A study published in the Journal of Immunology suggests that the combined blockade of excess release of catecholamines (CAs) and prostaglandins (PGs) in cancer patients undergoing tumor excision might improve survival rates and prevent cancer recurrence. The surgical procedure, a common step in the treatment of most solid cancers, has long been suspected to facilitate […]

Substance P Promotes Th17 Phenotype in Generalized Anxiety Disorder

Substance P Promotes Th17 Phenotype in Generalized Anxiety Disorder

A study published in the journal of Clinical Immunology demonstrates that the cytokine profiles in generalized anxiety disorder (GAD) individuals show traits of Th1 and Th2 deficiencies but are associated with a predominant Th17 phenotype, particularly in the presence of substance P (SP). Substance P has been shown to stimulate the inflammatory response, contributing to […]

Pro- and Anti-Inflammatory Effects of Stress in the Brain: Mechanisms and Implications

Pro- and Anti-Inflammatory Effects of Stress in the Brain: Mechanisms and Implications

Overview Article Some stress protocols show a pro-inflammatory response in the brain and other systems characterized by a complex release of several inflammatory mediators such as cytokines, transcription factors, prostanoids and free radicals. Such response might contribute to cell damage during several neuropsychiatric diseases related with stress (post-traumatic stress disorder, major depressive disorder, anxiety disorders, […]

Stress and Disorders of the Stress System

Stress and Disorders of the Stress System

A recent article published in Nature Reviews Endocrinology provides a brief but comprehensive overview on the conceptual evolution, and current understanding of homeostasis and the pathogenic disturbances that are associated with stress and the disorders of the stress system. Homeostasis, a term coined by the American physiologist Walter Cannon in the beginning of the 20th […]

Childhood Roots of Health Disparities

Childhood Roots of Health Disparities

Recently, in the Journal of the American Medical Association (JAMA), Jack Shonkoff, W. Thomas Boyce and Bruce McEwen discussed a new way of thinking about health promotion and disease prevention. Adult conditions such as coronary heart disease, stroke, diabetes, and cancer are believed to be causally related to adult behavior and lifestyles only. But recent […]

Stress, Proinflammation, Autoregulation and Cardiovascular Diseases

Stress, Proinflammation, Autoregulation and Cardiovascular Diseases

Overview Article Chronic stress can be an extremely detrimental phenomenon because it maintains an artificial state of excitation, whereas acute stress ends this process in a more timely manner. Therefore, it is not surprising to find proinflammatory phenomena occurring during chronic stress since the system maintains excitability, including that of immune origin. The cardiovascular system […]

Stress Response in Childhood Asthma

Stress Response in Childhood Asthma

Overview Article Accumulated evidence from animal models suggests that exogenously applied stress enhances airway reactivity and increases airway inflammation. This is considered to be the result of their inability to increase glucocorticoid production in response to stress to suppress the immune reaction. Clinical observations that stressful life events in asthmatic subjects increase the risk of […]

Hans Selye and the Birth of the Stress Concept

Hans Selye and the Birth of the Stress Concept

Historical Perspectives In 1936 a half page report appeared in Nature magazine under the title “A syndrome produced by diverse nocuous agents,” which was authored by Hans Selye of McGill University, Montreal, Canada [1]. The essence of this report was that rats exposed to a variety of nocuous or toxic agents (e.g. cold, surgery, forced […]

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