stress and cancer

First Evidence That Psychological Stress Alters Levels Of Suppressor Cells in Breast Cancer

First Evidence That Psychological Stress Alters Levels Of Suppressor Cells in Breast Cancer

A new study in Cellular Immunology is perhaps the first to specifically measure levels of myeloid-derived suppressor cells (MDSC) in post operative breast cancer patients who were considered to be macroscopically disease-free. In this study, Bethany Mundy-Bosse and colleagues from the Department of Integrated Biomedical Sciences, the Ohio State University, Columbus OH investigated the association […]

Stress and Cancer: A Link Through the Chinese Cultural Revolution

Stress and Cancer: A Link Through the Chinese Cultural Revolution

Overview Article It is now well recognized that preventive health care requires going beyond the immediate causes of diseases and understanding their fundamental socio-economic determinants. Cancer is one of these diseases that has emerged as the top killer, both physically and economically, surpassing heart disease, in many high-income countries. Does stress contribute to these increasing […]

Biobehavioral Factors, Stress and Cancer Progression: A Contemporary Review

Biobehavioral Factors, Stress and Cancer Progression: A Contemporary Review

In two recent reviews, published in 2011, Erin Costanzo, Anil Sood and Susan Lutgendorf provide a contemporary overview of the major pathways involved in the cross-talk between behavioral factors and the immune system that contribute to cancer development  and progression. The idea that psychological factors may contribute to cancer development and progression is not new. […]

Stress May Restrain the Immunostimulatory Effects of Interleukin-12

Stress May Restrain the Immunostimulatory Effects of Interleukin-12

A new study published in the journal Brain, Behavior, and Immunity suggests that chronic stress exposure can abolish the effects of immunostimulatory treatments such as the administration of interleukin (IL)-12, which is independent from the stress effects on baseline immune measures. Type 1 T-helper (Th)1 and proinflammatory cytokines are major activators of Th1-dependent cellular immunity, […]

The Stress(ed) World and Hans Selye

The Stress(ed) World and Hans Selye

SHORT FEATURES and FACES ARTICLE 80 years after Hans Selye introduced the concept and term ‘stress’ there is a very substantial body of evidence that psychological stress is linked to the pathogenesis of several common human diseases. According to the American Institute of Stress, stress is America’s #1 health problem. Two-thirds of all office visits […]

Beta Blockers Hold Substantial Potential for Therapeutical Interventions in Cancer

Beta Blockers Hold Substantial Potential for Therapeutical Interventions in Cancer

Evolving Concepts Recently, more than 10 studies [see References 1-11], published in the last 3-4 years indicate the presence of high intratumoral concentrations of catecholamines and that these neurohormonal mediators affect key components of tumor biology such as tumor growth, angiogenesis, and migration or invasion [for details see References 12-13]. These studies suggest that blocking […]

Celebrities, Stress and Cancer

Celebrities, Stress and Cancer

SHORT FEATURES and FACES ARTICLE Recently, several websites have reported that Michael Douglas has been diagnosed with throat cancer. The actor believes a combination of his previous hard-driving lifestyle and the stresses of the past 12 months may have caused the cancer. He tells UK’s Daily Mirror that stress was a major factor: “This type […]

Neurobiology of Cancer

Neurobiology of Cancer

In a Personal View article, published in The Lancet Oncology Katarina Ondicova and Boris Mravec address a timely topic of growing interest, the role of the nervous system or the neurobiology of cancer etiopathogenesis. Circa 200 A.D. Galen, the Greek physician and philosopher was perhaps the first to link ‘cancer’ with the person’s emotional and […]

The Sympathetic Nervous System as a Regulator of Breast Cancer Metastasis

The Sympathetic Nervous System as a Regulator of Breast Cancer Metastasis

A study published in the journal Cancer Research identifies sympathetic nervous system (SNS) activation as a novel physiologic regulator of breast cancer metastasis to distant tissue sites. The effects of the neuroendocrine system and microenvironment on breast cancer metastasis remain largely unexplored. Sympathetic nervous system nerve fibers are present in organs that serve as key […]

A Combination of Beta-Adrenergic Antagonist and Cyclooxygenase-2 Inhibitor Improves Survival Rates in Murine Models of Postoperative Metastasis

A Combination of Beta-Adrenergic Antagonist and Cyclooxygenase-2 Inhibitor Improves Survival Rates in Murine Models of Postoperative Metastasis

A study published in the Journal of Immunology suggests that the combined blockade of excess release of catecholamines (CAs) and prostaglandins (PGs) in cancer patients undergoing tumor excision might improve survival rates and prevent cancer recurrence. The surgical procedure, a common step in the treatment of most solid cancers, has long been suspected to facilitate […]

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