stress and cancer

Stress and Your Health: From Vulnerability to Resilience

Stress and Your Health: From Vulnerability to Resilience is published by Wiley-Blackwell and is authored by Hymie Anisman, Professor in the Department of Neuroscience at Carleton University, Ottawa, Canada Research Chair in Neuroscience and Fellow of the Royal Society of Canada. The Stress and Your Health presents an evidence-based evaluation of the various effects of […]

More Evidence that Norepinephrine and β3-Adrenoreceptors May Drive Melanoma Progression & Aggressiveness

More Evidence that Norepinephrine and β3-Adrenoreceptors May Drive Melanoma Progression & Aggressiveness

A report recently published in Oncotarget shows that the β3-adrenoreceptors are involved in melanoma aggressiveness, and that these receptors, expressed on several accessory cells, may orchestrate their function and thus, sustain melanoma progression. Recent research indicates that stress and stress mediators contribute to cancer development and/or progression. It appears that in this process a major […]

Psychoneuroimmunology: Stress, Mental Disorders and Health (Progress in Psychiatry)

Another excellent book devoted to the interdisciplinary area of research known as psychoneuroimmunology (PNI). The field bridges together psychiatry, neurology, neuroendocrinology and immunology. The book is the result of a collaborative work of many international experts including Cobi J. Heijnen, Pranela Rameshwar, Nancy G. Klimas and many others. Psychoneuroimmunology: Stress, Mental Disorders and Health deals […]

Stress-Induced β2-Adrenoceptor-Mediated M2 Macrophage Polarization Promoting Tumor Growth in a Mouse Model of Breast Cancer

Stress-Induced β2-Adrenoceptor-Mediated M2 Macrophage Polarization Promoting Tumor Growth in a Mouse Model of Breast Cancer

A new study published in the BMB Reports indicates that stress hormones such as epinephrine (adrenaline) may promote the transformation of M1-type macrophages to M2-type macrophages and, thus, accelerate tumor growth in a mouse model of breast cancer. Several studies have linked psychological stress and breast cancer risk, associating with the involvement of stress mediators […]

Sympathetic Neuropathy Linked To the Development of Myeloproliferative Neoplasms

Sympathetic Neuropathy Linked To the Development of Myeloproliferative Neoplasms

A new study published in the August 07, 2014 issue of Nature magazine reveals that an impaired neuro-endocrine microenvironment of the bone marrow plays a crucial role in the development and clinical outcome of myeloproliferative neoplasms (MPNs). This and related studies may represent a breakthrough in hematology research and a paradigm shift in the MPNs’ […]

Cool Housing Temperature and Cold Stress Linked To Immunosuppression and Increased Tumor Growth in Experimental Animals

Cool Housing Temperature and Cold Stress Linked To Immunosuppression and Increased Tumor Growth in Experimental Animals

In the December 2013 issue of the Proceedings of the National Academy of Sciences of the USA Kathleen Kokolus et al., from the Roswell Park Cancer Institute, Buffalo, NY and the US Environmental Protection Agency, NC, demonstrate that a cool ambient housing temperature may affect the outcome of a broad range of experimental endpoints, including […]

New Animal Stress Model Links the Stress-Induced T-helper 2 Shift to Colon Cancer Growth

New Animal Stress Model Links the Stress-Induced T-helper 2 Shift to Colon Cancer Growth

In the October 2013 issue of Biochemical and Biophysical Research Communications, Ni Hou and colleagues from the Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi, China, demonstrated that a novel form of sound stress induced a T helper (Th)2 shift and that this is related to colon cancer progression in mice. Numerous epidemiological reports indicate […]

Beta Adrenoreceptor – Src Kinase Signaling As a Trigger for Cancer Metastasis

Beta Adrenoreceptor – Src Kinase Signaling As a Trigger for Cancer Metastasis

In the July 2013 issue of Nature Communications, Armaiz-Pena et al. demonstrate that stress is able through activation of beta-adrenergic signaling in tumor cells to trigger a critical phosphorylation event, resulting in Src kinase activation, which in turn, can affect tumor growth and metastasis. Building on previous work showing that sympathetic nervous system activity can […]

Breast cancer survivors consider stress as major factor for their disease

Breast cancer survivors consider stress as major factor for their disease

According to a report and survey published in Psychooncology a substantial part of women who had survived breast cancer believe that there is a link between breast cancer and psychological stress. In this report, Stewart DE et al., from the University Health Network Women’s Health Program, University of Toronto, Canada surveyed 378 women breast cancer […]

Stress promotes tumor growth by amplifying the cancer cells’ ability to evade apoptosis

Stress promotes tumor growth by amplifying the cancer cells’ ability to evade apoptosis

A study published in the Journal of Clinical Investigation indicates that stress or the stress hormone adrenaline, through stimulation of beta-adrenoreceptors (ADRs), activate signaling pathways that lead to the inhibition of apoptosis. This enables prostate cancer cells to evade apoptosis, which is an important feature of tumor growth and metastasis. An increasing body of evidence […]

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