stress and asthma

Anxiety, Depression and Obesity May Jointly Contribute To Asthma Development

Anxiety, Depression and Obesity May Jointly Contribute To Asthma Development

A recent study by M. Brumpton et al., published in the International Journal of Epidemiology has shed light on the complex interactions and joint effects of anxiety, depression and obesity on the onset and development of asthma. Approximately 300 million people suffer from asthma, amounting to nearly 1% of the total global disease burden, worldwide. […]

Further Evidence That Prenatal Exposure to Stress May Increase the Risk of Asthma Development in Later Life

Further Evidence That Prenatal Exposure to Stress May Increase the Risk of Asthma Development in Later Life

A recent study published in the BioMed Research International journal suggests that maternal stress during pregnancy is able to increase offspring risk and susceptibility to asthma. Previous research indicates that prenatal and early-life stress can modify infant immune function in the long-term, including conferring a higher risk for childhood asthma (MK Pincus-Knackstedt et al., 2006; […]

Childhood Adversities and the Development of Asthma in Adulthood

Childhood Adversities and the Development of Asthma in Adulthood

Recently the BMJ Open online journal published the first large-scale prospective, population-based study, involving 24 057 participants, followed for a 7-year period, documenting an association between childhood adversities and register-verified asthma diagnosis in adulthood. Previous research has shown that anxiety disorders and major depression are linked to asthma development, and two previous longitudinal studies reported […]

New Evidence That Stress In Pregnancy Increases Susceptibility to Asthma In Offspring

New Evidence That Stress In Pregnancy Increases Susceptibility to Asthma In Offspring

A recent study published in the American Journal of Physiology – Lung Cellular and Molecular Physiology indicates that release of glucocorticoids (GCs) as the result of stress during pregnancy can induce asthma susceptibility in offspring. It is known that psychological stress contributes to the pathogenesis and exacerbations of asthma. One mechanism may be the capacity […]

Viruses and Glucocorticoids ‘Cooperate’ to Induce Interleukin-10 Production: Implications for Stress-Induced Immunosuppression and Exacerbations of Asthma

Viruses and Glucocorticoids ‘Cooperate’ to Induce Interleukin-10 Production: Implications for Stress-Induced Immunosuppression and Exacerbations of Asthma

A study published in the May 2013 issue of PLoS One may indicate a novel, unrecognized interaction between viruses and the glucocorticoid (GC)-signaling system that results in the induction of interleukin (IL)-10 production by dendritic cells (DCs). In this report, Sinnie Ng and colleagues from the National Institutes of Child Health and Human Development, and […]

Neurotensin, CRH and Mast Cell Activation: Implications for Stress-Induced Exacerbations of Allergic Diseases

Neurotensin, CRH and Mast Cell Activation: Implications for Stress-Induced Exacerbations of Allergic Diseases

A study published in PLoS One indicates the presence of distinctive interactions between neurotensin (NT), corticotropin-releasing hormone (CRH) and mast cells that may be involved in inflammatory- and/or stress-related diseases. Psychological stress is known to aggravate asthma, migraines and certain autoimmune/inflammatory diseases. Although the mechanisms of stress-induced exacerbations of these conditions are not fully understood, […]

Signaling Through Neuropeptide Y1 Receptor – a Critical Pathway in Allergic Inflammation

Signaling Through Neuropeptide Y1 Receptor – a Critical Pathway in Allergic Inflammation

In a new Immunology & Cell Biology study, Laurence Macia and colleagues from the Garvan Institute of Medical Research, Darlinghurst, Australia, demonstrate that Neuropeptide Y (NPY) exacerbates allergic airway inflammation (AAI) in mice, via its Y1 receptor.  Neuropeptide Y (NPY) is a 36 amino acid peptide discovered in 1982 by Kazuhiko Tatemoto, Mats Carlquist and Viktor Mutt. NPY signals […]

The Stress-Susceptible Individual and the Risk for Inflammatory Diseases

The Stress-Susceptible Individual and the Risk for Inflammatory Diseases

SHORT FEATURES and FACES ARTICLE In this recent editorial Gailen Marshall, Editor-in-Chief of Annals of Allergy, Asthma & Immunology, discusses the topic of identifying and stratifying stress-susceptible individuals and established patients, and the relevance of correlating this susceptibility to the presence and/or progression of immune-mediated inflammatory conditions. An increasing body of evidence suggests stress is […]

Stress Response in Childhood Asthma

Stress Response in Childhood Asthma

Overview Article Accumulated evidence from animal models suggests that exogenously applied stress enhances airway reactivity and increases airway inflammation. This is considered to be the result of their inability to increase glucocorticoid production in response to stress to suppress the immune reaction. Clinical observations that stressful life events in asthmatic subjects increase the risk of […]