Sjogren’s syndrome

New Evidence Implicating IL-21 in Sjögren’s Syndrome

New Evidence Implicating IL-21 in Sjögren’s Syndrome

A study published in the journal Cornea provides new evidence that the pro-inflammatory cytokine interleukin (IL)-21 may contribute to the development and severity of Sjögren’s syndrome. Primary Sjögren’s syndrome is an autoimmune disease causing dry eyes and dry mouth, and featuring mononuclear and plasma cell infiltration in the salivary and lacrimal glands. Recent research indicates that […]

Novel TRAIL+ NK Cell Subset May Restrain Autoreactivity in Viral Infections: Implications For Sjogren’s Disease and Virus-Induced Autoimmunity

Novel TRAIL+ NK Cell Subset May Restrain Autoreactivity in Viral Infections: Implications For Sjogren’s Disease and Virus-Induced Autoimmunity

A new study published in the journal Immunity reveals a new role of TRAIL-expressing NK cells during chronic viral infection that may provide further insights into the link between viruses and autoimmune disease development. The TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) is known to induce apoptosis and selective toxicity for cancer cells. However, TRAIL also inhibits autoimmune […]