Reuters, BBC and other major media reported that the World Health Organization (WHO) warned on Monday that, despite strong hopes for a vaccine, there might never be a ‘silver bullet’ for COVID-19. In addition, the WHO stated that the road to normality would be long with some countries requiring a reset of their current strategies. […]
Commentary On: Viral and host factors related to the clinical outcome of COVID-19, by Zhang et al., Nature, 2020 Jul;583(7816):437-440. doi: 10.1038/s41586-020-2355-0. The COVID-19 outbreak was first identified in Wuhan, China. Despite the causal agent being closely related to a bat coronavirus (RaTG13), several questions remain regarding the origin, evolution and host interaction of COVID-19. […]
Following the recommendation of the European Medicines Agency (EMA), the European Commission has authorized on Friday, July 3rd, the use of remdesivir to treat severe cases of COVID-19. Recently, the EMA and its human medicines committee (CHMP) recommended the drug’s use in adults and adolescents of at least 12 yrs of age with severe cases […]
First Evidence that the Antiviral Remdesivir Shows Efficacy in an Animal Model (Rhesus Macaques) of COVID-19
As reported by Brandi Williamson et al. in bioRxiv, remdesivir is the first antiviral treatment with proven efficacy against SARS-CoV-2 in an animal model of COVID-19. This study involving four laboratories from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) and the Gilead Sciences, Foster City, CA, USA, indicates […]
Commentary Note that the information contained herein is NOT instructional for medical diagnosis or treatment, see the BrainImmune DISCLAIMER at the end of this article! The pandemic viral illness COVID-19 is especially life-threatening in the elderly and in people with any of a variety of underlying medical conditions. No conceptual framework has been offered as […]
β2-Adrenoceptor-Mediated Upregulation of IL-17 May Contribute to Pulmonary Immunopathology in COVID-19: Does Blockade of IL-17 and β-Adrenergic Effects Hold a Therapeutic Potential?
Research Hypothesis Note that this is a research hypothesis – the information contained herein is NOT instructional for medical diagnosis or treatment, see the BrainImmune DISCLAIMER at the end of this article! It has been reported that nucleotide-binding oligomerization domain 2 (NOD2) can also function as a cytoplasmic viral pattern recognition receptor (PRR) by triggering […]