rheumatoid arthritis

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor Agonists in a Murine Model of Rheumatoid Arthritis

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor Agonists in a Murine Model of Rheumatoid Arthritis

According to van Maanen et al., and their recent publication in PLoS One, two new experimental compounds affecting the acetylcholine-receptor system are able to delay collagen-induced arthritis (CIA) in mice, showing the therapeutic potential of chemicals targeting the α7 subunit of nicotinic acetylcholine receptors (α7nAChR). Previous research revealed that the efferent vagus nerve may decrease […]

Blood Levels of the New Anti-Inflammatory Cytokine IL-37 Are Increased In Rheumatoid Arthritis Patients

Blood Levels of the New Anti-Inflammatory Cytokine IL-37 Are Increased In Rheumatoid Arthritis Patients

A recent study published in PLoS One suggests that interleukin (IL)-17 is involved in a control circuit that tries to regulate inflammation in rheumatoid arthritis. Rheumatoid arthritis (RA) is associated with increased levels of pro-inflammatory cytokines such as IL-6, IL-17A and tumor necrosis factor (TNF)-α. Early intervention and treatment of RA is based on disease-modifying […]

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

Commentary on the study by George Schett et al, Nat Med, 2013 Jul;19(7):822-4 How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy Extensive genome-wide association and epidemiological studies have shed light on the causes of chronic inflammatory diseases and have confirmed a central role of the immune system and particularly of cytokines [1]. Secreted […]

Stress and Worrying Affect Short-Term Fluctuations in Rheumatoid Arthritis Symptoms

Stress and Worrying Affect Short-Term Fluctuations in Rheumatoid Arthritis Symptoms

In the July 2013 issue of Annals of Rheumatic Diseases, Evers et al. report that stress and worrying predict indicators of rheumatoid arthritis disease activity such as fatigue and pain. Psychological stress has been linked to the onset and course of rheumatoid arthritis (RA). While for the juvenile chronic arthritis (JCA), chronic stress appear to […]

Drug Companies and NIH in $230 Million Joint Project for Alzheimer’s, Diabetes, Lupus and Arthritis

Drug Companies and NIH in $230 Million Joint Project for Alzheimer’s, Diabetes, Lupus and Arthritis

Along with funding from the United States government and ten large pharmaceutical companies, the National Institutes of Health (NIH), Bethesda, Maryland will split the cost of a new multimillion project targeting common chronic human diseases. The companies involved include Pfizer Inc., Eli Lilly & Co, AbbVie Inc., Biogen Idec Inc., Bristol-Myers Squibb Co., Glaxo Smith […]

New Evidence That Testosterone Provides Protection against Arthritis

New Evidence That Testosterone Provides Protection against Arthritis

A recent study by Rebecca Keith and coworkers from the National Jewish Health, Denver, CO, US, published in Arthritis and Rheumatism, provides further experimental evidence that testosterone deficiency might play a role in the development of arthritis. It is well known that sex hormones are involved in the pathogenesis of rheumatoid arthritis (RA). In addition, […]

Stress and Rheumatic Diseases

Stress and Rheumatic Diseases

SHORT FEATURES and FACES ARTICLE In an editorial published in Arthritis Research & Therapy, Afton Hassett and Daniel Clauw, of University of Michigan Medical School, discuss some aspects of the complex interactions between psychological stress and the onset, expression and progression of rheumatic diseases. The authors mention that some studies in this research area are […]

Pregnancy and Rheumatoid Arthritis

Pregnancy and Rheumatoid Arthritis

Overview article Rheumatoid arthritis (RA) is a systemic, chronic inflammatory disorder, characterized by symmetrical polyarthritis and presence of extra-articular manifestations including subcutaneous nodules, lung disease, pericarditis, hematopoietic disturbances, neuropathy, and vasculitis. RA occurs in 0.5 to 1% of the population with a female to male ratio of 3:1 and with an increasing incidence with advancing […]

Hypothalamic-Pituitary-Adrenal Axis Function in Rheumatoid Arthritis

Hypothalamic-Pituitary-Adrenal Axis Function in Rheumatoid Arthritis

Overview article The neuroendocrine and the immune system are important homeostatic mechanisms maintaining the integrity of the organism. The efficacy of these homeostats in dynamic internal and external environments is a basis for successful adaptation to endogenous and exogenous stimuli that the organism constantly encounters. The adaptive reactions are complex and their ‘self-protecting’ nature serves […]

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