First Evidence of Sensory Nerves Driving Interleukin-23 Production in Skin: A Breakthrough in Psoriasis Research?
A study published in the June 05, 2014 issue of Nature magazine indicates that sensory nerve-driven interleukin-(IL)-23 production by dermal dendritic cells (DDCs) contributes to psoriasis-like inflammation. These findings may represent a breakthrough in psoriasis research and the understanding of the pathogenesis of this skin disease. The IL-23→IL-17 axis plays a major role in the […]
Interactions Among IL-33, Substance P and Mast Cells May Contribute to the Pathogenesis of Psoriasis
A new study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) indicates that substance P (SP) stimulates human mast cells to secrete vascular endothelial growth factor (VEGF) and that this action is augmented by interleukin (IL)-33. Substance P-positive nerve ﬁbers are denser in psoriatic lesions and […]