perispinal delivery

An Evolving Concept: The Pathologic Level of Brain TNF is a Therapeutic Target for Chronic Pain Treatment

An Evolving Concept: The Pathologic Level of Brain TNF is a Therapeutic Target for Chronic Pain Treatment

Evolving Concept Chronic pain is a serious healthcare dilemma with many treatment options available, such as antidepressants, non-steroidal anti-inflammatory drugs, opioids, and anticonvulsants; nevertheless, chronic pain presently is not appropriately managed. A fundamental reason for the lack of effective treatment is that none of these drugs specifically target a process that is essential in eliciting […]

Perispinal Delivery of CNS Drugs: From Corning to Perispinal Etanercept

Perispinal Delivery of CNS Drugs: From Corning to Perispinal Etanercept

Evolving Concepts Introduction Familiarity with the anatomy and physiology of the cerebrospinal venous system (CSVS) is necessary to understand the therapeutic potential of perispinal injection for treatment of central nervous system (CNS) disorders [1, 2]. The CSVS is composed of the confluence of the venous systems of the spine and the brain, which together constitute […]