norepinephrine

A Sympathetic-Adrenal Neuroimmune Reflex Linked to the Immunosuppressive Effects of Spinal Cord Injury

A Sympathetic-Adrenal Neuroimmune Reflex Linked to the Immunosuppressive Effects of Spinal Cord Injury

A recent study published in Nature Neuroscience indicates that the increased susceptibility to life-threatening infections in spinal cord injury (SCI) patients may result from the disruption of the physiological interactions within a neuroendocrine reflex involving the sympathetic nervous system (SNS) and the adrenal glands. The control of the immune system by the peripheral autonomic nervous […]

Norepinephrine May Shift the IL-12/IL-23 Ratio of Dendritic Cells towards IL-23 Predominance thus Favoring Th17 Differentiation

Norepinephrine May Shift the IL-12/IL-23 Ratio of Dendritic Cells towards IL-23 Predominance thus Favoring Th17 Differentiation

A new study published in the January 15, 2016 issue of the Journal of Immunology indicates that in murine bone marrow–derived dendritic cells (DCs), norepinephrine, via stimulation of β2-adrenoceptors, is able to promote a shift in the IL-12p70/IL-23 cytokine ratio. Primary and secondary lymphoid organs receive a rich autonomic nervous system innervation, mainly by the […]

Handbook of Neurochemistry and Molecular Neurobiology: Neurotransmitter Systems 3rd Edition

A classic book about several basic concepts and the latest developments in the field of neurochemistry and neuroscience. The Handbook of Neurochemistry and Molecular Neurobiology is the result of a collaborative work of numerous established experts worldwide. The volume covers several research areas such as in vivo imaging of neurotransmitter systems, molecular genetics of the […]

Massage May Affect Immunity via the Sympathetic Innervation and Noradrenaline Release

Massage May Affect Immunity via the Sympathetic Innervation and Noradrenaline Release

Fulvio D`Acquisto and colleagues from Queen Mary University of London, UK recently showed that 8 days of massage-like therapy (hand- but not brush-stroked mice) resulted in modulation of murine immune system’s parameters through the sympathetic innervation and noradrenaline release. Massage per se apparently had no effect on anxiety-like behaviors in mice, but the immunomodulatory effects […]

New Evidence that Stress Mediators Directly Affect Hematopoiesis and Increase Neutrophil and Monocyte Production

New Evidence that Stress Mediators Directly Affect Hematopoiesis and Increase Neutrophil and Monocyte Production

A study published in Nature Medicine suggests that stress mediators may also directly activate hematopoi­etic stem cells (HSCs), which increase proliferation and differentiate into downstream progenitor cells, with the end result of an accelerated neutrophil and monocyte production. Acute stress is known to induce a transient leukocytosis, mostly due to an increase in natural killer […]

Cool Housing Temperature and Cold Stress Linked To Immunosuppression and Increased Tumor Growth in Experimental Animals

Cool Housing Temperature and Cold Stress Linked To Immunosuppression and Increased Tumor Growth in Experimental Animals

In the December 2013 issue of the Proceedings of the National Academy of Sciences of the USA Kathleen Kokolus et al., from the Roswell Park Cancer Institute, Buffalo, NY and the US Environmental Protection Agency, NC, demonstrate that a cool ambient housing temperature may affect the outcome of a broad range of experimental endpoints, including […]

Biobehavioral Factors, Stress and Cancer Progression: A Contemporary Review

Biobehavioral Factors, Stress and Cancer Progression: A Contemporary Review

In two recent reviews, published in 2011, Erin Costanzo, Anil Sood and Susan Lutgendorf provide a contemporary overview of the major pathways involved in the cross-talk between behavioral factors and the immune system that contribute to cancer development  and progression. The idea that psychological factors may contribute to cancer development and progression is not new. […]

Aging and Alterated Sympathetic Innervation of Lymphoid Organs in Rodents: Implications

Aging and Alterated Sympathetic Innervation of Lymphoid Organs in Rodents: Implications

A study in Journal of Neuroimmunology suggests that aging is linked to significant alterations in the sympathetic nervous innervation of lymphoid organs that may contribute to aging-related immunosuppression, The sympathetic nervous system (SNS) is a major branch of the autonomic nervous system and the peripheral stress system. The function of the human SNS is altered […]

Cold-Induced Sympathoexcitation and Adipokine Profiles in Humans

Cold-Induced Sympathoexcitation and Adipokine Profiles in Humans

A study published in the journal Metabolism suggests that the sympathetic nervous system (SNS) and its activation during cold-induced stress activation may play an important role in the regulation of adipokine secretion. Adipose tissue, in tight interconnection with the SNS, has a key role in maintaining energy homeostasis, blood pressure control, immunoregulation, hemostasis, and atherosclerosis. […]