neuropeptide Y

Neuropeptide Y, Pro-Inflammatory Cytokines and Atherosclerotic Plaque Instability

Neuropeptide Y, Pro-Inflammatory Cytokines and Atherosclerotic Plaque Instability

A recent study by Pankajakshan et al., published in Experimental and Molecular Pathology, reports the presence of neuropeptide Y (NPY)-Y2 receptors’ expression, and a pronounced cytokine-induced up-regulation of NPY-Y2 expression in carotid atherosclerotic plaques. The study suggests that NPY, a sympathetic nervous system (SNS) neurotransmitter and stress mediator may modulate the effects of pro-inflammatory cytokines […]

Maternal Stress, Neuropeptide Y System and the Offspring’s Vulnerability to Obesity and Metabolic Syndrome

Maternal Stress, Neuropeptide Y System and the Offspring’s Vulnerability to Obesity and Metabolic Syndrome

A recent report in the FASEB Journal indicates that Neuropeptide Y (NPY) system is a potential mediator of programming for the offspring’s vulnerability to obesity and metabolic syndrome induced by maternal low-protein diet (LPD). According to CDC more than one-third of U.S. adults (35.7%) are obese. As stated by Ogden C. et al., 17.1% of […]

Signaling Through Neuropeptide Y1 Receptor – a Critical Pathway in Allergic Inflammation

Signaling Through Neuropeptide Y1 Receptor – a Critical Pathway in Allergic Inflammation

In a new Immunology & Cell Biology study, Laurence Macia and colleagues from the Garvan Institute of Medical Research, Darlinghurst, Australia, demonstrate that Neuropeptide Y (NPY) exacerbates allergic airway inflammation (AAI) in mice, via its Y1 receptor.  Neuropeptide Y (NPY) is a 36 amino acid peptide discovered in 1982 by Kazuhiko Tatemoto, Mats Carlquist and Viktor Mutt. NPY signals […]