neuroimmunology neuroendocrine-immunology

Neuroendocrine Immunology in 2014 – What Was Hot and Some Conceptual Trends as Presented on BrainImmune

Neuroendocrine Immunology in 2014 – What Was Hot and Some Conceptual Trends as Presented on BrainImmune

Editorial In 2014 we witnessed a rapid growth of the research and studies at the interface and intersection of neurosciences and immunology. This vast interdisciplinary area, often referred to as neuroendocrine immunology or neuroimmunology, also includes stress-immune interactions that may have complex and multifaceted impact on health and disease. Last year also brought some interesting […]

Sex Hormones and Immunoregulation

Sex Hormones and Immunoregulation

Overview article The sexual dimorphism in immune responses in humans is well known; females have more vigorous cellular and humoral immune responses, they are more resistant to many infections, and they suffer a higher incidence of autoimmune diseases as compared with males [reviewed in Reference 1]. Moreover, in women disease expression appears to be affected […]

Brain-Immune Signaling: Focus on Pathogen Recognition and PGE2 Synthesis

Brain-Immune Signaling: Focus on Pathogen Recognition and PGE2 Synthesis

Overview article The body’s reaction to infections involves the orchestration of multiple systems to effectively initiate, execute and resolve the immune response. At the core of these adaptive processes are the cellular and molecular neural, immune and endocrine interactions that begin with the central nervous system recognizing the presence of an infection. The mediator prostaglandin […]

Nerve Growth Factor and Inflammation: A Complex Bidirectional Interaction

Nerve Growth Factor and Inflammation: A Complex Bidirectional Interaction

Overview article The nervous and immune systems share common functions: both are involved in adapting the body to the environment and in maintaining homeostasis. Because they are the two major adaptive systems of the body it is not surprising that they have developed common strategies: both are able to sense external and internal variations, which […]

The Neuroimmune Biology of Vasopressin

The Neuroimmune Biology of Vasopressin

Overview article Vasopressin (VP) has emerged in recent years as a very important immunoregulatory peptide of the hypothalamus. VP is capable of maintaining immune function, both innate and adaptive immunity. This is due to the ability of VP to stimulate both the hypothalamic-pituitary-adrenal (HPA) axis and prolactin (PRL) secretion. The HPA axis is important for […]

Mainstream Immunology Research and Cultural Separation

Mainstream Immunology Research and Cultural Separation

Editorials & Opinion One of the curious aspects of modern biomedicine is the “cultural separation” of immunology research from neurobiology and physiology research. One can argue that the failure to link the immune system to the brain (and vice versa) has played a role in the immunology’s minimal progress from the bench to the bedside […]