myocardial infarction

First Evidence that IL-9 Contributes to Atherosclerosis Development

First Evidence that IL-9 Contributes to Atherosclerosis Development

Perhaps the first evidence for an involvement of IL-9 in atherosclerosis was recently reported in the online journal PLoS One by Ida Gregersen and colleagues from the Oslo University Hospital Rikshospitalet, Oslo, Norway. Interleukin (IL)-9 is a cytokine linked mostly to T helper (Th)2 cell responses and Th2-related conditions such as parasitic helminth infections and […]

Colchicine May Prove Useful In the Treatment of Acute Coronary Syndrome

Colchicine May Prove Useful In the Treatment of Acute Coronary Syndrome

A study by Gonzalo Martınez et al., published in the Journal of the American Heart Association indicates that colchicine may also be useful for the treatment of heart attacks by reducing cardiac inflammation and the local pro-inflammatory cytokine production. Colchicine is an alkaloid with potent anti-inflammatory effects, which is often used for the treatment of […]

The Emerging Role of Innate Immune Cells’ Network and the Cardio-Splenic Axis in Heart Failure

The Emerging Role of Innate Immune Cells’ Network and the Cardio-Splenic Axis in Heart Failure

A new study published in the journal Circulation Research is perhaps the first to show changes of the innate cells network and traffic in ischemic heart failure. Heart failure (HF) remains a major health issue, and evidence accumulated over the last decade has established immune activation or inflammation as a major pathogenic factor in chronic […]

Increased Risk of Heart Attack Linked To Polymorphism in the 5HTR2C Serotonin Receptor Gene

Increased Risk of Heart Attack Linked To Polymorphism in the 5HTR2C Serotonin Receptor Gene

In the December 2013 issue of PLOS One, a research team from the Department of Psychiatry, Duke University Medical Center, Durham, NC reports that a functional polymorphism of the 5HTR2C gene is associated with a 38% increased risk for cardiovascular disease events. This includes mortality and myocardial infarction (MI), independent of several traditional risk factors, […]

Chlamydophila pneumonia phospholipase D is a potent inducer of Th17 inflammation in atherosclerosis

Chlamydophila pneumonia phospholipase D is a potent inducer of Th17 inflammation in atherosclerosis

A recent article in PNAS indicates that Chlamydophila pneumoniae phospholipase D (CpPLD) is a major C. pneumoniae factor able to induce Th17 immune response in atherosclerosis. It is known that atherosclerosis/carotid disease pathology and symptomatology might be causally related to the presence of Chlamydophila pneumoniae. Phospholipases (PLs), a heterogeneous group of proteins with enzymatic activity, […]

Elevated Plasma IL-10 Levels are a Strong Predictor of Long-Term Adverse Outcomes in Acute Coronary Syndrome

Elevated Plasma IL-10 Levels are a Strong Predictor of Long-Term Adverse Outcomes in Acute Coronary Syndrome

Interleukin (IL)-10 is often considered as a ‘cardioprotective’ cytokine, but a recent study published in the American Journal of Medicine reports an ‘unexpected’ observation that elevated baseline plasma levels of IL-10 are a strong predictor of long-term adverse cardiovascular outcomes in patients with acute coronary syndrome. Interleukin-10 is an immunoregulatory cytokine with strong anti-inflammatory properties. […]