microbial deprivation hypothesis

Microbial Deprivation, Inflammation and the Th17/IL-23 Axis in Cancer Development

Microbial Deprivation, Inflammation and the Th17/IL-23 Axis in Cancer Development

In a recent review article in Cancer and Metastasis Reviews Leena von Hertzen, H. Joensuu and T. Haahtela, from the Skin and Allergy Hospital, Helsinki University Central Hospital, Finland, summarize the epidemiological data related to microbe-rich environments and cancer, and discuss the involvement of the T helper (Th)17/Interleukin(IL)-23 axis and the immunomodulatory potential of environmental microbiota […]

The ‘Old Friends’ Hypothesis and Why Living in the Modern World May Increase Vulnerability to Major Depression

The ‘Old Friends’ Hypothesis and Why Living in the Modern World May Increase Vulnerability to Major Depression

In this paper, Raison et al. explore evidence that the ‘old friends’ theory, heretofore associated with allergic and autoimmune diseases, can also be applied to major depression. The ‘old friends’ theory suggests that immune interactions with pseudocommensal mycobacterial species, gut flora members and helminthes regulate the immune system, thus explaining lower rates of atopic (Th2-mediated) […]