macrophage

Raloxifene and Two New Selective Estrogen Receptor Modulators (SERMs) Inducing M2-Macrophage Shift and High IL-10 and IL-1Ra Production

Raloxifene and Two New Selective Estrogen Receptor Modulators (SERMs) Inducing M2-Macrophage Shift and High IL-10 and IL-1Ra Production

A new study published in the journal Inflammation indicates that in myeloid cells raloxifene and two new selective estrogen receptor modulators (SERMs) are able to induce a shift to M2-macrophage anti-inflammatory phenotype, characterized by high production of interleukin (IL)-10 and IL-1 receptor antagonist (IL-1Ra). Estrogens exert pleiotropic immuno-modulatory and immuno-regulatory effects, contributing to the sexual […]

First Evidence that Macrophages Modulate Heart Electrical Conduction System

First Evidence that Macrophages Modulate Heart Electrical Conduction System

In a recent Cell study, Maarten Hulsmans et al. report the presence of abundant resident macrophages in the heart atrioventricular (AV) node, and provide first evidence that these cells modulate the electrical conduction and activity of cardiomyocytes. This phenomenon may be related to the pathogenic electrical conduction in heart conditions such as atrial fibrillation and […]

Stress-Induced β2-Adrenoceptor-Mediated M2 Macrophage Polarization Promoting Tumor Growth in a Mouse Model of Breast Cancer

Stress-Induced β2-Adrenoceptor-Mediated M2 Macrophage Polarization Promoting Tumor Growth in a Mouse Model of Breast Cancer

A new study published in the BMB Reports indicates that stress hormones such as epinephrine (adrenaline) may promote the transformation of M1-type macrophages to M2-type macrophages and, thus, accelerate tumor growth in a mouse model of breast cancer. Several studies have linked psychological stress and breast cancer risk, associating with the involvement of stress mediators […]