leukocyte migration

New Evidence that Stress Mediators Directly Affect Hematopoiesis and Increase Neutrophil and Monocyte Production

New Evidence that Stress Mediators Directly Affect Hematopoiesis and Increase Neutrophil and Monocyte Production

A study published in Nature Medicine suggests that stress mediators may also directly activate hematopoi­etic stem cells (HSCs), which increase proliferation and differentiate into downstream progenitor cells, with the end result of an accelerated neutrophil and monocyte production. Acute stress is known to induce a transient leukocytosis, mostly due to an increase in natural killer […]

Sympathetic neural control of circadian oscillations in leukocyte migration

Sympathetic neural control of circadian oscillations in leukocyte migration

In the August 2012 issue of Immunity, Scheiermann et al. describe a series of experiments that elegantly illustrate the patterns of leukocyte homing to the bone marrow and recruitment to skeletal muscle, and how they are affected by photic and adrenergic input. Scheiermann et al. begin by establishing that circadian oscillations are present in peripheral […]

Autonomic Nervous System Control of Leukocyte Distribution: Physiology and Implications for Common Human Diseases

Autonomic Nervous System Control of Leukocyte Distribution: Physiology and Implications for Common Human Diseases

Overview article Leukocytes are key components of the body’s defense system and the major subsets of leukocytes are granulocytes and lymphocytes. We and others have found that the distribution of these subsets are under the regulation of the autonomic nervous system. Of note, granulocytes express adrenergic receptors and the number and proportion of granulocytes increase […]