interleukin-10

Deficiency of IL-10 in Chronic Fatigue Syndrome?

Deficiency of IL-10 in Chronic Fatigue Syndrome?

A new 2015 study, published in the Mediators of Inflammation journal suggests a deficiency of interleukin (IL)-10 in chronic fatigue syndrome (CFS). Chronic fatigue syndrome/myalgic encephalomyelitis, an illness characterized by unexplained fatigue lasting 6 months or more, is often linked to dysfunctional neuroendocrine and immune responses, including abnormal production of several cytokines (NG Klimas & […]

Chronic Stress and IL-10/STAT3 Pathway’s Induction

Chronic Stress and IL-10/STAT3 Pathway’s Induction

A study published in Brain, Behavior, and Immunity journal indicates that the interleukin (IL)-10/STAT3 pathway may play a key role in the immunosuppression induced by chronic stress. IL-10 is a major anti-inflammatory cytokine, which possesses potent immunosuppressive actions. Stress mediators, particularly catecholamines (CAs), are potent IL-10 inducers, and in clinical conditions such as brain trauma, […]

Accumulation of Myeloid-Derived Suppressor Cells: A New Mechanism in Favor of Stress-Induced Immunosuppression?

Accumulation of Myeloid-Derived Suppressor Cells: A New Mechanism in Favor of Stress-Induced Immunosuppression?

Jianfeng Jin et al. present a mechanism for the immunosuppressive potential of chronic stress in the September 2013 issue of PLoS One. The authors focus on myeloid-derived suppressor cells (MDSCs), which have been implicated in regulation of the innate and adaptive immune responses. In tumor microenvironments, MDSC expansion is stimulated by prostaglandin E2 (PGE2) and […]

Cold-Induced Stress May Promote Chlamydia Genital Infection

Cold-Induced Stress May Promote Chlamydia Genital Infection

A recent study by Tesfaye Belay and Anthony Woart from the School of Arts and Sciences, Bluefield State College, Bluefield, WV, is perhaps the first to document a link between cold (weather) stress and the course of Chlamydia trachomatis infection. This common sexually transmitted infection is known to cause severe complications such as pelvic inflammatory […]

Autonomic Nervous System Shift Linked to Infections following Acute Intracerebral Hemorrhage

Autonomic Nervous System Shift Linked to Infections following Acute Intracerebral Hemorrhage

A report in the journal Stroke indicates that a sympathetic nervous system over-activity and predominance is associated with higher rate of infection following acute intracerebral hemorrhage (ICH). Stroke is a major cause of morbidity and the third leading cause of death in the Western world. Infections occur commonly following stroke and adversely influence outcome. Pulmonary […]

Elevated Plasma IL-10 Levels are a Strong Predictor of Long-Term Adverse Outcomes in Acute Coronary Syndrome

Elevated Plasma IL-10 Levels are a Strong Predictor of Long-Term Adverse Outcomes in Acute Coronary Syndrome

Interleukin (IL)-10 is often considered as a ‘cardioprotective’ cytokine, but a recent study published in the American Journal of Medicine reports an ‘unexpected’ observation that elevated baseline plasma levels of IL-10 are a strong predictor of long-term adverse cardiovascular outcomes in patients with acute coronary syndrome. Interleukin-10 is an immunoregulatory cytokine with strong anti-inflammatory properties. […]

Regulatory T Cells are Cerebroprotective in Acute Experimental Stroke

Regulatory T Cells are Cerebroprotective in Acute Experimental Stroke

A recent Nature Medicine study by Arthur Liesz et al. indicates that regulatory T cells (Treg) are cerebroprotective after experimental brain ischemia or stroke, and that interleukin (IL)-10 appears to be the major mediator of the cerebroprotective effects. Recent evidence indicates that inflammatory mechanisms such as up-regulation of pro-inflammatory cytokines and leukocytes’ invasion in the […]