inflammasome

The Innate Immune System Senses Psychological Stress through the ATP/P2X7R-Inflammasome (NLRP3) Cascade

The Innate Immune System Senses Psychological Stress through the ATP/P2X7R-Inflammasome (NLRP3) Cascade

Commentary on the study by Masaaki Iwata et al., Biological Psychiatry, 2015, doi: 10.1016/j.biopsych.2015.11.026. Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor Mental disorders are a very common condition. However, the pathophysiology of many of these disorders still remains elusive and more importantly, a very […]

Corticotropin-Releasing Hormone’s Inhibition of NLRP6 Inflammasome May Trigger Stress-Induced Enteritis in Mice

Corticotropin-Releasing Hormone’s Inhibition of NLRP6 Inflammasome May Trigger Stress-Induced Enteritis in Mice

In the June 2013 issue of Gastroenterology, Sun et al. demonstrate that in mice stress is able to inhibit NLRP6, through a corticotropin-releasing hormone (CRH)-dependent mechanism and to modify the composition of the gut microbiota, leading to intestinal inflammation. It is well known that psychological stress exacerbates the symptoms of irritable bowel syndrome (IBS). Also, […]