immunosuppression

Teach the T Cells: Learned Immunosuppressive Placebo Responses in Renal Transplant Patients

Teach the T Cells: Learned Immunosuppressive Placebo Responses in Renal Transplant Patients

After organ transplantation or chronic inflammatory autoimmune diseases, patients depend on immunosuppressive medication for the rest of their lives, which can cause severe side effects. A recent study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) suggests that learned immunosuppressive placebo responses increased efficacy of immunosuppressive medication […]

Chronic Stress and IL-10/STAT3 Pathway’s Induction

Chronic Stress and IL-10/STAT3 Pathway’s Induction

A study published in Brain, Behavior, and Immunity journal indicates that the interleukin (IL)-10/STAT3 pathway may play a key role in the immunosuppression induced by chronic stress. IL-10 is a major anti-inflammatory cytokine, which possesses potent immunosuppressive actions. Stress mediators, particularly catecholamines (CAs), are potent IL-10 inducers, and in clinical conditions such as brain trauma, […]

Bungee Jumping Related Stress Response May Suppress Innate Immunity Through the Activation of a Noncanonical Glucocorticoid Signaling Pathway

Bungee Jumping Related Stress Response May Suppress Innate Immunity Through the Activation of a Noncanonical Glucocorticoid Signaling Pathway

In this study, David van Westerloo and colleagues from the University of Amsterdam report that bungee jumping resulted in a time-dependent increase in the plasma concentrations of epinephrine, norepinephrine and cortisol; decreased whole blood production of TNF-alpha and IL-8, and a substantial reduction of bacterial phagocytosis by granulocytes and monocytes. Bungee jumping may represent an […]