The Chemokines CX3CL1 and IL-8 May Be Implicated in the Pathogenesis of Fibromyalgia
A new study published in the Journal of Pain Research reports the presence of high levels of the chemokines CX3CL1 (also known as fractalkine) and interleukin-8 (IL-8) in fibromyalgia (FM) patients. Fibromyalgia is the “current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified”. Typical symptoms includes chronic widespread pain, […]
An Association between Widespread Pain and Serum IL-8 Levels in Fibromyalgia Patients
Ozdolap S, et al. recently reported, at the European League against Rheumatism Annual European Congress of Rheumatology, June 10-13, 2015, a positive correlation between widespread pain and serum IL-8 in patients with fibromyalgia (FM). Fibromyalgia is characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues, and women are more likely to […]
First Report That Interleukin-17A Levels Are Increased In Fibromyalgia Patients
A recent study by Andrei Pernambuco and colleagues from the Federal University of Minas Gerais, Belo Horizonte, MG, Brazil is perhaps the first to document increased plasma levels of interleukin (IL)-17A in fibromyalgia (FM) patients. Interleukin-17 and the T helper (Th)-17 cells play a key role in tissue inflammation and host defense and, recently, the […]
Immune & Cytokine Dysregulation Associated With Behavioral Deficits In A Mouse Model Of Autism
A new report in the Proceedings of the National Academy of Sciences of the USA (PNAS) indicates that cellular and cytokine immune dysregulation may contribute to the autism spectrum disorder (ASD)-related behavioral deficits in a mouse model of an autism. Recent evidence indicates the involvement of an abnormal immune system activity in the pathogenesis of […]
Cytokine Profiles in Subjects with Autism Spectrum Disorders
In a study published in the online journal PLoS ONE, a research group from the Hamamatsu University School of Medicine, Hamamatsu, Japan reports the presence of high levels of several pro-inflammatory cytokines in male (≥6 years old) subjects with autism spectrum disorder (ASD). ASD include autistic disorder, Asperger’s disorder and pervasive developmental disorder. A dysregulation […]
