Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma
A recent Journal of Translational Medicine study indicates that interleukin (IL)-33 is produced by bronchial smooth muscle cells (BSMCs) upon rhinovirus (RV) infection and activation of TLR3, and that this response is associated and/or mediated by ATP released by viral-stimulated BSMCs. IL-33 is a cytokine constitutively expressed in epithelial barrier tissues, and was originally described […]
Interactions Among IL-33, Substance P and Mast Cells May Contribute to the Pathogenesis of Psoriasis
A new study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) indicates that substance P (SP) stimulates human mast cells to secrete vascular endothelial growth factor (VEGF) and that this action is augmented by interleukin (IL)-33. Substance P-positive nerve fibers are denser in psoriatic lesions and […]
Overview of the ”New Generation” Cytokines
In this review, published in Arthritis Research & Therapy Cem Gabay and Iain McInnes present the biology and relevant pathophysiology of several novel cytokines, with focus on their involvement in rheumatic diseases. This list includes the interleukin (IL)-1 superfamily (IL-18 and IL-33), the IL-12 superfamily (IL-27 and IL-35), the IL-2 superfamily (IL-15 and IL-21), and […]
