IL-27

First Evidence that Catecholamines Inhibit IL-27 Production by Antigen Presenting Cells

First Evidence that Catecholamines Inhibit IL-27 Production by Antigen Presenting Cells

A recent J. Immunology study provides perhaps the first evidence that catecholamines such as norepinephrine and epinephrine suppress the production of interleukin-27 (IL-27) via the activation of β2-adrenoceptors, and by mechanisms involving IL-10 and the JNK signaling pathway. Homeostasis within the immune system is largely dependent on cytokines, the ‘hormones’ of the immune system that […]

IL-27 and IFN-Gamma Cooperate to Induce Steroid Resistance in Asthma

IL-27 and IFN-Gamma Cooperate to Induce Steroid Resistance in Asthma

The mechanisms driving steroid resistance in asthma are poorly understood, but a new study published in Journal of Immunology indicates that a novel interleukin (IL)-27– and interferon (IFN)-γ–driven pathway may contribute to this process, where the activation of MyD88-dependent pathways in macrophages may play a critical role. The major downstream molecules that regulate IFN-gamma and […]

Overview of the ”New Generation” Cytokines

Overview of the ”New Generation” Cytokines

In this review, published in Arthritis Research & Therapy Cem Gabay and Iain McInnes present the biology and relevant pathophysiology of several novel cytokines, with focus on their involvement in rheumatic diseases. This list includes the interleukin (IL)-1 superfamily (IL-18 and IL-33), the IL-12 superfamily (IL-27 and IL-35), the IL-2 superfamily (IL-15 and IL-21), and […]