IL-12

Blocking IL-12 and IL-23 in APPPS1 Mouse Model Shows Promise as an Experimental Therapeutic Approach to Alzheimer’s Disease

Blocking IL-12 and IL-23 in APPPS1 Mouse Model Shows Promise as an Experimental Therapeutic Approach to Alzheimer’s Disease

A recent study, published in Nature Medicine is perhaps the first one to show interleukin (IL)-23 involvement, and implicates both IL-23 and IL-12, key pro-inflammatory cytokines in the pathogenesis of Alzheimer’s disease. Importantly, it also demonstrates that in the APPPS1 Alzheimer’s disease mouse model, preventing the effects of these mediators, or ‘immune hormones’, with antibodies […]

Chronic Stress and IL-10/STAT3 Pathway’s Induction

Chronic Stress and IL-10/STAT3 Pathway’s Induction

A study published in Brain, Behavior, and Immunity journal indicates that the interleukin (IL)-10/STAT3 pathway may play a key role in the immunosuppression induced by chronic stress. IL-10 is a major anti-inflammatory cytokine, which possesses potent immunosuppressive actions. Stress mediators, particularly catecholamines (CAs), are potent IL-10 inducers, and in clinical conditions such as brain trauma, […]

Immune & Cytokine Dysregulation Associated With Behavioral Deficits In A Mouse Model Of Autism

Immune & Cytokine Dysregulation Associated With Behavioral Deficits In A Mouse Model Of Autism

A new report in the Proceedings of the National Academy of Sciences of the USA (PNAS) indicates that cellular and cytokine immune dysregulation may contribute to the autism spectrum disorder (ASD)-related behavioral deficits in a mouse model of an autism. Recent evidence indicates the involvement of an abnormal immune system activity in the pathogenesis of […]

1,25-Dihydroxyvitamin D3 Transcriptional Repression of Interleukin-17A Expression and Th17-Related Autoimmunity

1,25-Dihydroxyvitamin D3 Transcriptional Repression of Interleukin-17A Expression and Th17-Related Autoimmunity

In a new Molecular and Cellular Biology study, Sneha Joshi and colleagues from the University of Medicine and Dentistry of New Jersey, Newark demonstrate that the reversal of paralysis in EAE mice by 1,25-Dihydroxyvitamin D3 correlates with reduced IL-17A-secreting CD4+ T cells, and that the mechanism involved in 1,25-Dihydroxyvitamin D3-mediated suppression of IL-17A induction involves […]

Stress May Restrain the Immunostimulatory Effects of Interleukin-12

Stress May Restrain the Immunostimulatory Effects of Interleukin-12

A new study published in the journal Brain, Behavior, and Immunity suggests that chronic stress exposure can abolish the effects of immunostimulatory treatments such as the administration of interleukin (IL)-12, which is independent from the stress effects on baseline immune measures. Type 1 T-helper (Th)1 and proinflammatory cytokines are major activators of Th1-dependent cellular immunity, […]

Cytokine Profiles in Subjects with Autism Spectrum Disorders

Cytokine Profiles in Subjects with Autism Spectrum Disorders

In a study published in the online journal PLoS ONE, a research group from the Hamamatsu University School of Medicine, Hamamatsu, Japan reports the presence of high levels of several pro-inflammatory cytokines in male (≥6 years old) subjects with autism spectrum disorder (ASD). ASD include autistic disorder, Asperger’s disorder and pervasive developmental disorder. A dysregulation […]

Priming of Murine Bone Marrow-Derived Dendritic Cells with Epinephrine Favors the Induction of a Dominant Th2/Th17 Phenotype

Priming of Murine Bone Marrow-Derived Dendritic Cells with Epinephrine Favors the Induction of a Dominant Th2/Th17 Phenotype

A new study published in the journal Brain, Behavior, and Immunity indicates that the stress hormone epinephrine (also known as adrenaline) is able to drive a Th2/Th17-shift in dendritic cells (DCs) in the presence of a pathogenic stimulus. Dendritic cells cytokine and chemokine profiles are able to shape CD4+ T cell pathways and phenotypes and […]