hippocampus

Hyperactive Type I Interferon System in the Choroid Plexus Linked To Aging and Cognitive Dysfunction

Hyperactive Type I Interferon System in the Choroid Plexus Linked To Aging and Cognitive Dysfunction

A study published in the August 21, 2014 issue of Science magazine demonstrates that aging is associated with an overactive interferon (IFN)-I system at a specific brain structure, the choroid plexus. This vascular tissue, found in all cerebral ventricles, is an epithelial monolayer that forms the blood-cerebrospinal fluid barrier, and, in fact, represents the ‘interface’ […]

Stress, the Reward System and the Epidemic of Obesity

Stress, the Reward System and the Epidemic of Obesity

SHORT FEATURES and FACES ARTICLE A recent review by Rajita Sinha and Ania Jastreboff from the Yale Stress Center, New Haven, CT, USA, provides an integrative perspective on the neurohormonal mechanisms by which stress affects reward pathways, and how the interactions between the stress and reward systems may contribute to the epidemic of obesity. In […]

Ucp2 Induction by Natural Birth and Hippocampus Development

Ucp2 Induction by Natural Birth and Hippocampus Development

A recent report published in the August issue of PLoS One indicates that natural (vaginal) birth but not Caesarian section birth in mice triggers uncoupling protein 2 (Ucp2) expression in hippocampal neurons. Mitochondrial Ucp2 is a critical determinant of fatty acid utilization by adult neurons and is involved in cell proliferation, neuroprotection and synaptogenesis in […]

New Evidence That Anxiety and Vulnerability to Stress Contribute to the Development of Dementia

New Evidence That Anxiety and Vulnerability to Stress Contribute to the Development of Dementia

In a recent American Journal of Geriatric Psychiatry study, Robert Wilson and colleagues from the Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL examined the relation of different facets of neuroticism to risk of developing AD. Emerging research implicates a consistent reciprocal relationship between late-life anxiety and cognition, and that severe anxiety may […]

A Mechanism Linking Immune Cells Activities, Biomarkers and Hippocampal Volume Loss to Post-Traumatic Stress Disorder

A Mechanism Linking Immune Cells Activities, Biomarkers and Hippocampal Volume Loss to Post-Traumatic Stress Disorder

In a recent review in Journal of Neurochemistry, James Andrews and Kameran Neises from the Naval Health Research Center, San Diego, California provide up to date information, and a brief but comprehensive overview on how peripheral blood mononuclear cells (PBMCs) and biomarkers may play a role in a putative mechanism and effective diagnosis of PTSD. […]

Robert Sapolsky and Why Zebras Don’t get Ulcers

Robert Sapolsky and Why Zebras Don’t get Ulcers

SHORT FEATURES and FACES ARTICLE Robert Sapolsky, a neuroendocrinologist and John A. and Cynthia Fry Gunn Professor at Stanford University, has focused his research on issues of stress and neuronal degeneration, as well as on the possibilities of gene therapy strategies for protecting susceptible neurons from disease. In his Science article, entitled ‘Why Stress Is […]