GM-CSF

Further Evidence That the Cytokine GM-CSF is an Essential Factor in the Pathogenesis of Multiple Sclerosis

Further Evidence That the Cytokine GM-CSF is an Essential Factor in the Pathogenesis of Multiple Sclerosis

Rasouli et al., published in the June 1st issue of the Journal of Immunology reports that treatment-naive MS patients had greater numbers of GM-CSF+ T cells in the peripheral blood, whereas CD4+ and CD8+ T cells in MS brain lesions expressed GM-CSF. In addition, interferon (INF)-β suppressed GM-CSF production by T cells, in vitro conditions. […]

New Subset of T Helper Cells May Play a Critical Role in Multiple Sclerosis

New Subset of T Helper Cells May Play a Critical Role in Multiple Sclerosis

A study by Wanqiang Sheng and colleagues from the National University of Singapore, published in Cell Research identifies a new subset of T helper (Th) cells that may play a key role in autoimmune neuroinflammatory conditions such as multiple sclerosis. Recent evidence indicates that granulocyte-macrophage colony-stimulating factor (GM-CSF) is a major encephalitogenic factor contributing to […]