glucocorticoids and asthma

Viruses and Glucocorticoids ‘Cooperate’ to Induce Interleukin-10 Production: Implications for Stress-Induced Immunosuppression and Exacerbations of Asthma

Viruses and Glucocorticoids ‘Cooperate’ to Induce Interleukin-10 Production: Implications for Stress-Induced Immunosuppression and Exacerbations of Asthma

A study published in the May 2013 issue of PLoS One may indicate a novel, unrecognized interaction between viruses and the glucocorticoid (GC)-signaling system that results in the induction of interleukin (IL)-10 production by dendritic cells (DCs). In this report, Sinnie Ng and colleagues from the National Institutes of Child Health and Human Development, and […]

IL-27 and IFN-Gamma Cooperate to Induce Steroid Resistance in Asthma

IL-27 and IFN-Gamma Cooperate to Induce Steroid Resistance in Asthma

The mechanisms driving steroid resistance in asthma are poorly understood, but a new study published in Journal of Immunology indicates that a novel interleukin (IL)-27– and interferon (IFN)-γ–driven pathway may contribute to this process, where the activation of MyD88-dependent pathways in macrophages may play a critical role. The major downstream molecules that regulate IFN-gamma and […]