gastrointestinal tract

Corticotropin-Releasing Hormone’s Inhibition of NLRP6 Inflammasome May Trigger Stress-Induced Enteritis in Mice

Corticotropin-Releasing Hormone’s Inhibition of NLRP6 Inflammasome May Trigger Stress-Induced Enteritis in Mice

In the June 2013 issue of Gastroenterology, Sun et al. demonstrate that in mice stress is able to inhibit NLRP6, through a corticotropin-releasing hormone (CRH)-dependent mechanism and to modify the composition of the gut microbiota, leading to intestinal inflammation. It is well known that psychological stress exacerbates the symptoms of irritable bowel syndrome (IBS). Also, […]

New Link between Gut Microbes, Sex Hormones and Autoimmunity Protection

New Link between Gut Microbes, Sex Hormones and Autoimmunity Protection

A recent report by Janet Markle et al., in Science magazine, identifies a possible causative link between gut microbiota and sex hormone production that may drive protection from autoimmunity. The human gastrointestinal (GI) tract houses an extensive microbial ecosystem, represented by trillions of microorganisms located in our intestines. In fact, there are 10 times more […]

Combat-training stress and high pro-inflammatory markers in soldiers linked to increased intestinal permeability and gastrointestinal symptoms

Combat-training stress and high pro-inflammatory markers in soldiers linked to increased intestinal permeability and gastrointestinal symptoms

A study published in the February 2013 issue of Alimentary Pharmacology and Therapeutics reports that soldiers participating in as little as 6 weeks of combat training had high stress; anxiety and depression levels combined with gastrointestinal (GI) symptoms, pro-inflammatory immune activation and increased intestinal permeability. Gastrointestinal symptoms in soldiers are among the most common causes […]