estrogens

Raloxifene and Two New Selective Estrogen Receptor Modulators (SERMs) Inducing M2-Macrophage Shift and High IL-10 and IL-1Ra Production

Raloxifene and Two New Selective Estrogen Receptor Modulators (SERMs) Inducing M2-Macrophage Shift and High IL-10 and IL-1Ra Production

A new study published in the journal Inflammation indicates that in myeloid cells raloxifene and two new selective estrogen receptor modulators (SERMs) are able to induce a shift to M2-macrophage anti-inflammatory phenotype, characterized by high production of interleukin (IL)-10 and IL-1 receptor antagonist (IL-1Ra). Estrogens exert pleiotropic immuno-modulatory and immuno-regulatory effects, contributing to the sexual […]