estrogen

Reproduction and Fertility Linked to the Estradiol’s Regulation of NF-κb Translocation in Dendritic Cells

Reproduction and Fertility Linked to the Estradiol’s Regulation of NF-κb Translocation in Dendritic Cells

A new study published in Genes & Immunity may explain why some immune responses, and particularly dendritic cells (DCs) functions are restrained during ovulation. The menstrual cycle is related to subtle changes in sex hormone levels (see Cover Image) that may have, however, profound effects on innate and adaptive immune responses. Estradiol levels, which are […]

Sperm-Induced Th17 Immune Responses and Their Control by Sex Hormones: Implications for Fertility

Sperm-Induced Th17 Immune Responses and Their Control by Sex Hormones: Implications for Fertility

A new study by Miguel Relloso and colleagues from the Hospital General Universitario Gregorio Marañón in Madrid, Spain, identifies the female sex hormones as important regulators of the T helper (Th)17 response induced by sperm, and related to dendritic cells (DCs), the key professional antigen-presenting cells. Sperm is a foreign antigen (material) and its contact […]

Tumor Necrosis Factor – a Possible Link Between Age-Related Endocrine Dyscrasia and Alzheimer’s Disease

Tumor Necrosis Factor – a Possible Link Between Age-Related Endocrine Dyscrasia and Alzheimer’s Disease

In a commentary recently published in the Journal of Alzheimer’s Disease, Ian Clark and Craig Atwood discussed some novel mechanisms and viewpoints related to the “cross-talk” between tumor necrosis factor (TNF) and endocrine dyscrasia, and how this might affect the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), stroke and traumatic brain disease. Endocrine dyscrasia […]

Estrogens and Dendritic Cells

Estrogens and Dendritic Cells

A study published in the Journal of Immunology demonstrates that estrogens may boost innate immunity by enhancing interferon (IFN)-γ production by CD11c(+) dendritic cells. In humans, the sex differences or the sexual dimorphism in immune defense is a well-known phenomenon. Females have more vigorous cellular and humoral immune responses, and they are more resistant to […]