estradiol

Reproduction and Fertility Linked to the Estradiol’s Regulation of NF-κb Translocation in Dendritic Cells

Reproduction and Fertility Linked to the Estradiol’s Regulation of NF-κb Translocation in Dendritic Cells

A new study published in Genes & Immunity may explain why some immune responses, and particularly dendritic cells (DCs) functions are restrained during ovulation. The menstrual cycle is related to subtle changes in sex hormone levels (see Cover Image) that may have, however, profound effects on innate and adaptive immune responses. Estradiol levels, which are […]

Estradiol – a Classic Neurotransmitter in the Brain?

Estradiol – a Classic Neurotransmitter in the Brain?

Recent evidence indicates that, besides their hormonal actions at the genetic level, estrogens such as 17 beta-estradiol also influence brain function by direct effects on neuronal membranes. Thus, brain-derived estrogens are increasingly considered genuine neuromodulators. It is unclear, however whether neuroestrogen production is controlled via electrochemical events that are the hallmark of neurotransmitter-based cell-to-cell communication. […]