estradiol and brain

Estradiol – a Classic Neurotransmitter in the Brain?

Estradiol – a Classic Neurotransmitter in the Brain?

Recent evidence indicates that, besides their hormonal actions at the genetic level, estrogens such as 17 beta-estradiol also influence brain function by direct effects on neuronal membranes. Thus, brain-derived estrogens are increasingly considered genuine neuromodulators. It is unclear, however whether neuroestrogen production is controlled via electrochemical events that are the hallmark of neurotransmitter-based cell-to-cell communication. […]