depression

The Neuroimmunological Basis of Behavior and Mental Disorders

The Neuroimmunological Basis of Behavior and Mental Disorders is published by Springer and edited by Allan Siegel, Ph.D. and Steven S. Zalcman, Ph.D. Neurosciences and immunology developed independently for many years, and thus, the question of how the brain communicates with the immune system remained enigmatic until fairly recently. The immune system has been regarded […]

Cytokines, Stress, and Depression (Advances in Experimental Medicine and Biology)

Cytokines, Stress, and Depression is edited by Robert Dantzer, Emmanuelle E. Wollmann and Raz Yirmiya, and published by Springer. Cytokines had been characterized in the early eighties as communication mole­cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of […]

The Evolving Link between Social Media Addiction and Depression in Young Adults

The Evolving Link between Social Media Addiction and Depression in Young Adults

Recently, in the journal Pediatrics, Elizabeth Hoge, MD, David Bickham, PhD and Joanne Cantor, PhD outlined recent evidence that the social media addiction breeds and catalyzes anxiety and depression in children. In the US some teens spend about nine hours daily using media, whereas 24 percent of teenagers are online constantly, and 59% of children […]

Experimental Study Shows Link between Cerebrospinal Fluid IL-6 and Depressive Symptoms in Humans

Experimental Study Shows Link between Cerebrospinal Fluid IL-6 and Depressive Symptoms in Humans

A recent study published in Molecular Psychiatry suggests that the appearance of depressive symptoms in inflammatory conditions might be primarily linked to an increase in central IL-6 concentration. Inflammation is a physiological response to infection and tissue injury that involves the release of pro-inflammatory (e.g., TNF-α, IL-6) and anti-inflammatory (e.g., IL-10) cytokines from activated immune […]

High Levels of the Pro-Inflammatory Cytokines IL-1β and IL-6 Found in Patients with Suicidality

High Levels of the Pro-Inflammatory Cytokines IL-1β and IL-6 Found in Patients with Suicidality

A recent  study published in the journal Biological Psychiatry indicates the presence of aberrant cytokine levels in patients with suicidality, and identifies a link between pro-inflammatory cytokines, and specifically, interleukin (IL)-1β and IL-6 with suicidal behavior. Previous research has shown that major depression is associated with an immune response with an increased production of pro-inflammatory […]

Immigration and Stress: High Depression and Suicide Attempts Linked To Acculturative Stress in Indiana’s Latino Teens

Immigration and Stress: High Depression and Suicide Attempts Linked To Acculturative Stress in Indiana’s Latino Teens

Recently, a community-based study on the acculturative stress–depression link was presented at the American Public Health Association’s Annual Meeting and Exposition in New Orleans, Louisiana, Nov. 17. The term acculturation, coined in 1880 by John W. Powell refers to the modification of the culture of a group or individual as a result of contact with […]

Deficit of Oxytocin in Women with Major Depression

Deficit of Oxytocin in Women with Major Depression

A new study published in the Journal of Psychiatric Research extends the results of two previous studies and provides evidence that oxytocin levels are low in women with depression, including patients with psychotic major depression (PMD), who typically exhibit greater depressive severity. The neuropeptide oxytocin has been implicated in many aspects of reproductive and social […]

GrahamRook.net

Dr. Graham Rook is Emeritus Professor of Medical Microbiology at University College London. His website, contains a discussion of the evolutionary theory and immunological mechanisms behind the Old Friends mechanism, a reformulation of the hygiene hypothesis; the implications of faulty immunoregulation for psychiatry, and in particular for depression and stress resilience, and/or autoimmunity and cancer.  Read […]

The Role of Immunoregulating Microbes in Stress Resilience

The Role of Immunoregulating Microbes in Stress Resilience

In the March 2013 issue of Evolution, Medicine, and Public Health, Graham Rook et al. review a multitude of epidemiological data to highlight links between sanitation, psychiatric disorders and stress resilience. At the core of this concept is the Hygiene Hypothesis and “Old Friends” mechanism, which suggest that increased sanitation accounts for increases in inflammatory […]

Oxytocin & vasopressin and human emotional and behavioral systems

Oxytocin & vasopressin and human emotional and behavioral systems

A study, published on June 12, 2012, in PLoS One, provides perhaps the first evidence that oxytocin and arginine vasopressin are both dysregulated in Williams Syndrome. Human emotion and social behavior are linked to neuroendocrine function, and two hypothalamic neuropeptides, oxytocin (OT) and arginine vasopressin (AVP) appear to regulate reproduction, social behaviors and emotionality in […]

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