cytokines

Overview of the ”New Generation” Cytokines

Overview of the ”New Generation” Cytokines

In this review, published in Arthritis Research & Therapy Cem Gabay and Iain McInnes present the biology and relevant pathophysiology of several novel cytokines, with focus on their involvement in rheumatic diseases. This list includes the interleukin (IL)-1 superfamily (IL-18 and IL-33), the IL-12 superfamily (IL-27 and IL-35), the IL-2 superfamily (IL-15 and IL-21), and […]

Innate Immune Responses Linked to Seizures

Innate Immune Responses Linked to Seizures

A study published in the journal Brain indicates that the innate immune response to toll-like receptor 4 (TLR4) ligands, most likely involving activated microglia and release of interleukin (IL)-1, results in increased neuronal excitability sufficient to trigger experimental seizures in vivo. An increasing body of evidence suggests that inflammatory processes may play an important role […]

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